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Relapsing transverse myelitis.

D S Tippett1, P S Fishman, H S Panitch

  • 1Department of Neurology, University of Maryland School of Medicine, Baltimore 21201.

Neurology
|May 1, 1991
PubMed
Summary
This summary is machine-generated.

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Relapsing acute transverse myelitis, a rare condition, presents with recurrent spinal cord inflammation. This syndrome, distinct from multiple sclerosis, involves repeated episodes of neurological deficits.

Area of Science:

  • Neurology
  • Immunology

Background:

  • Acute transverse myelitis is typically a single-episode neurological disorder.
  • Recurrence often suggests alternative diagnoses like multiple sclerosis (MS).

Observation:

  • Three patients presented with recurrent, isolated acute transverse myelitis over 3-8 years.
  • Symptoms included sensory loss, paraparesis, and urinary retention, with specific spinal cord MRI findings.

Findings:

  • Patients showed no evidence of MS, collagen-vascular disease, or viral infection.
  • Cerebrospinal fluid lacked oligoclonal IgG bands, and cranial MRIs were normal.
  • High-dose corticosteroids led to stabilization and recovery between episodes.

Implications:

  • This suggests relapsing acute transverse myelitis may be an underrecognized syndrome.

Related Experiment Videos

  • It highlights the need to consider this distinct entity in patients with recurrent myelitis.
  • Further research is warranted to understand its pathogenesis and optimal management.