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Bone mass in healthy children: measurement with quantitative DXA
R N Southard1, J D Morris, J D Mahan
1Department of Pediatrics, Columbus Children's Hospital, College of Medicine, Ohio State University 43205.
Radiology
|June 1, 1991
Summary
Pubertal development and weight are key indicators of bone mass in children. This study provides normative data for lumbar vertebral bone mineral density, aiding in the detection of bone abnormalities in pediatric populations.
Area of Science:
- Pediatric Endocrinology
- Bone Densitometry
- Child Health
Background:
- Assessing bone mineral density in children is crucial for identifying potential health issues.
- Establishing normative data for pediatric bone mass is essential for accurate clinical interpretation.
Purpose of the Study:
- To investigate factors influencing lumbar vertebral bone mass in healthy children.
- To establish predictive models for bone mineral density in pediatric populations.
- To provide normative data for dual-energy x-ray bone densitometry in children.
Main Methods:
- Dual-energy x-ray bone densitometry (DXA) was utilized.
- 218 healthy children aged 1-19 years (134 girls, 84 boys) were included.
- Multiple regression analyses were performed to identify predictive indicators.
Main Results:
- Lumbar vertebral bone mass significantly increased with weight, age, and pubertal Tanner stage.
- Tanner stage and weight were identified as the strongest predictors of bone mass and bone mineral density.
- Age, sex, race, physical activity, and diet did not show significant influence when Tanner stage and weight were controlled.
Conclusions:
- Pubertal Tanner stage and weight are the primary determinants of bone mineral density in children.
- The study provides valuable normative data for lumbar vertebral bone mineral density, enhancing clinical assessment.
- Clinicians can utilize this data to better detect and monitor bone mineralization abnormalities in children.