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Pneumocystis carinii pneumonia complicating low dose methotrexate treatment for rheumatoid arthritis
A Wollner1, J Mohle-Boetani, R E Lambert
1Respiratory Medicine Division, Stanford University Medical Center, California 94305-5236.
Abstract:
Low dose methotrexate has been used effectively for various rheumatic and non-rheumatic diseases. Three cases of Pneumocystis carinii pneumonia occurring during treatment of rheumatoid arthritis with low dose methotrexate are presented. Several mechanisms might contribute to impaired immunity and the rare development of opportunist lung infection with methotrexate. A high degree of suspicion may result in earlier diagnosis and treatment.
Insights
Low dose methotrexate, used for rheumatic diseases, can rarely cause Pneumocystis pneumonia. Early suspicion and diagnosis are key for managing this opportunistic lung infection during methotrexate treatment.
Area of Science:
- Rheumatology
- Infectious Diseases
- Pharmacology
Background:
- Low dose methotrexate is a common treatment for various rheumatic and non-rheumatic conditions.
- Methotrexate can impact the immune system, potentially increasing infection risk.
- Opportunistic infections, like Pneumocystis pneumonia, are rare but serious side effects.