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Cutaneous Leishmaniasis in the Dorsal Skin of Hamsters: a Useful Model for the Screening of Antileishmanial Drugs
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Cutaneous Leishmaniasis in the Dorsal Skin of Hamsters: a Useful Model for the Screening of Antileishmanial Drugs

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Complement-fixing antibodies of lymphogranuloma venereum in mice; their development and response to sulfonamide

M J WALL

    Journal of Immunology (Baltimore, Md. : 1950)
    |March 19, 2010
    PubMed
    Abstract

    No abstract available in PubMed .

    Keywords:
    ANTIGENS AND ANTIBODIESCOMPLEMENT/fixationLYMPHOGRANULOMA VENEREUM/immunitySULFONAMIDES/effects

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    Leishmaniasis is a widespread parasitic disease caused by several Leishmania species. It affects millions of people each year and remains a major public health problem in endemic regions. First-line treatment relies on pentavalent antimonials, including meglumine antimoniate and sodium stibogluconate. Even so, how these drugs work has not been fully clear, especially their interaction with parasite-specific biochemical pathways. One key target is trypanothione reductase (TR), an enzyme that...

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