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Accurate and Simple Measurement of the Pro-inflammatory Cytokine IL-1β using a Whole Blood Stimulation Assay
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Published on: March 1, 2011

Behavioural effects of peripherally injected interleukin-1: role of prostaglandins

F Crestani1, F Seguy, R Dantzer

  • 1Laboratoire de Psychobiologie des Comportements Adaptatifs, INSERM U. 259, Université de Bordeaux II, France.

Brain Research
|March 1, 1991
PubMed

To investigate the possible mediation by prostaglandins of changes in behaviour induced by peripheral injection of interleukin-1 (IL-1), two types of behavioural tests were chosen, social exploration in mice and schedule-controlled behaviour in rats. Mice treated with 1 and 2.5 micrograms recombinant human IL-1 beta showed a time- and dose-dependent decrease in exploration of a juvenile conspecific. This effect was completely blocked by pretreatment with 10 mg/kg indomethacin or 10 mg/kg piroxicam, but not with 50 mg/kg aspirin. The disruption of operant responding induced by 5 micrograms IL-1 in rats was also suppressed by pretreatment with 5 mg/kg indomethacin or 10 mg/kg piroxicam. These results indicate that prostaglandins mediate the behavioural effects of peripherally injected IL-1.

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