Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Jun 14, 2026

Assaying Circuit Specific Regulation of Adult Hippocampal Neural Precursor Cells
08:52

Assaying Circuit Specific Regulation of Adult Hippocampal Neural Precursor Cells

Published on: July 24, 2019

[Conditional cell targeting and reversible synapse silencing to study neural circuits].

Dai Watanabe1

  • 1Department of Biological Sciences, Faculty of Medicine, Kyoto University, Yoshida, Sakyo-ku, Kyoto 606-8501, Japan.

Brain and Nerve = Shinkei Kenkyu No Shinpo
|March 20, 2010
PubMed
Summary

Researchers are developing advanced techniques to precisely target and control specific neuron populations. These methods, including immunotoxins and tetanus neurotoxin, aid in understanding neural circuit function and plasticity.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Brain Lesions Associated with Human Immunodeficiency Virus Infection in the Antiretroviral Therapy Era: A Single-center Experience in Japan.

Neurologia medico-chirurgica·2026
Same author

Cancer Risk in Men with HIV in Japan: An 18-Year Single-Center Cohort Study.

Cancers·2026
Same author

Early Diagnostic Value of Contrast-Enhanced MRI in Distinguishing Toxoplasmic Encephalitis from CNS Lymphoma: A Case Report of AIDS with Seronegative Toxoplasmosis.

Journal of the International Association of Providers of AIDS Care·2026
Same author

Regional heterogeneities of oligodendrocytes underlie biased Ranvier node spacing along single axons in sound localization circuit.

eLife·2025
Same author

The shifting burden of mortality among men with HIV in Japan between 2007 and 2024: a single-center retrospective cohort study.

BMC infectious diseases·2025
Same author

Month 12 outcomes of switching to long-acting cabotegravir + rilpivirine with an oral lead-in versus continuing bictegravir/emtricitabine/tenofovir alafenamide in the Phase 3b randomized SOLAR study.

Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy·2025

Area of Science:

  • Neuroscience
  • Molecular Biology
  • Cell Biology

Context:

  • Neural networks govern brain function and plasticity.
  • Understanding neural information processing requires precise manipulation of neuronal populations.
  • Mammalian brains contain diverse neuronal types, necessitating specific cell-targeting techniques.

Purpose:

  • To review technologies for precise neural circuit dissection.
  • To highlight immunotoxin-mediated conditional cell targeting.
  • To discuss tetanus neurotoxin-mediated reversible synapse silencing.

Summary:

  • Immunotoxins, antibody-toxin conjugates, enable conditional cell ablation based on target antigens.
  • Tetanus neurotoxin cleaves VAMP2, inhibiting synaptic transmission.

More Related Videos

Combining Optogenetics with Artificial microRNAs to Characterize the Effects of Gene Knockdown on Presynaptic Function within Intact Neuronal Circuits
09:17

Combining Optogenetics with Artificial microRNAs to Characterize the Effects of Gene Knockdown on Presynaptic Function within Intact Neuronal Circuits

Published on: March 14, 2018

Ex Vivo Optogenetic Interrogation of Long-Range Synaptic Transmission and Plasticity from Medial Prefrontal Cortex to Lateral Entorhinal Cortex
11:31

Ex Vivo Optogenetic Interrogation of Long-Range Synaptic Transmission and Plasticity from Medial Prefrontal Cortex to Lateral Entorhinal Cortex

Published on: February 25, 2022

Related Experiment Videos

Last Updated: Jun 14, 2026

Assaying Circuit Specific Regulation of Adult Hippocampal Neural Precursor Cells
08:52

Assaying Circuit Specific Regulation of Adult Hippocampal Neural Precursor Cells

Published on: July 24, 2019

Combining Optogenetics with Artificial microRNAs to Characterize the Effects of Gene Knockdown on Presynaptic Function within Intact Neuronal Circuits
09:17

Combining Optogenetics with Artificial microRNAs to Characterize the Effects of Gene Knockdown on Presynaptic Function within Intact Neuronal Circuits

Published on: March 14, 2018

Ex Vivo Optogenetic Interrogation of Long-Range Synaptic Transmission and Plasticity from Medial Prefrontal Cortex to Lateral Entorhinal Cortex
11:31

Ex Vivo Optogenetic Interrogation of Long-Range Synaptic Transmission and Plasticity from Medial Prefrontal Cortex to Lateral Entorhinal Cortex

Published on: February 25, 2022

  • Inducible transgenic systems allow reversible control of synaptic activity in specific neuronal pathways.

    • Impact:

    • Facilitates elucidation of neural circuit mechanisms.
    • Enables detailed study of neural operations and regulations.
    • Provides tools for investigating brain plasticity and information processing.