Phospholipid complexation of general anesthetics in fluid bilayers
Serhan Turkyilmaz1, Hideyuki Mitomo, Wen-Hua Chen
1Department of Chemistry, Lehigh University, Bethlehem, Pennsylvania 18015,USA.
None:
A nearest-neighbor recognition analysis has been performed in cholesterol-rich and cholesterol-poor liposomes derived from 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) in the presence of varying concentrations of chloroform. This analysis has yielded a fundamentally new, molecular-level view of the interaction of general anesthetics with lipid bilayers, which may be relevant to their biological action; that is, DPPC forms 1:1 complexes with CHCl(3) in both membranes in the fluid bilayer state.
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