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Updated: Jun 14, 2026
Enhancement of Facial Rejuvenation Through a Combination of 1565 nm Non-Ablative Fractional Laser with 30% Supramolecular Salicylic Acid
Published on: September 27, 2024
Skin tightening effect using fractional laser treatment II: A pilot animal study on skin remodeling
Teruki Dainichi1, Setsuko Ueda, Takeaki Fumimori
1Department of Dermatology, Kurume University School of Medicine, Fukuoka, Japan. dainichi@med.kurume-u.ac.jp
Background:
Fractional laser resurfacing is a new procedure for skin rejuvenation. We have found that it has a skin tightening effect in humans.
Objective:
To assess the mechanism of the skin tightening effect of fractional laser treatment in animals using histologic approaches.
Methods:
The dorsal skin of hairless guinea pigs was irradiated with a fractional 1,540-nm erbium glass laser. Biopsy specimens were taken serially from 0 hour until 1 year after irradiation and evaluated histologically.
Results:
Histologic evaluation indicated dermal remodeling within 2 months, in which regenerated collagen bundles and fibroblasts aligned in a horizontal direction, suggesting a traction stress on the dermal components. The treated part became less obvious over a period of more than 3 months by recovery of fine collagen bundles without fibrosis.
Conclusion:
These results suggest that improvement of the tension in a horizontal direction is essential for skin remodeling and improvement of facial laxity using fractional laser resurfacing.
