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Related Concept Videos

Angina II: Classification01:27

Angina II: Classification

Angina, also known as angina pectoris, is a chest pain resulting from diminished blood flow to the heart muscle and is often a symptom of coronary artery disease. Angina presents several variants with distinctive attributes, etiologies, and therapeutic approaches. The main types of angina include stable, unstable, variant (Prinzmetal's), microvascular, intractable, and silent ischemia.Stable angina is caused by atherosclerosis, which leads to the formation of plaques that narrow the coronary...
Angina I: Introduction01:30

Angina I: Introduction

Definition and Symptoms: Angina (angina pectoris) is chest pain or discomfort caused by myocardial ischemia, which occurs when the heart muscle receives insufficient oxygen-rich blood. It typically manifests as pressing, squeezing, or crushing sensations in the chest and may radiate to the shoulders, arms, neck, jaw, or back.Primary Cause: In a healthy state, the coronary arteries can dilate (widen) to increase blood flow and meet the increased oxygen demand during physical activity or...
Angina III: Clinical Manifestations and Assessment01:29

Angina III: Clinical Manifestations and Assessment

Angina manifests as chest pain, tightness, or squeezing discomfort typically located behind the breastbone. It can radiate to the neck, jaw, shoulders, and inner aspects of the upper arms, most commonly the left arm. Patients may experience shortness of breath, fatigue, profuse sweating, dizziness, indigestion, heartburn, palpitations, anxiety, and vomiting as accompanying symptoms. This pain often lasts a few minutes and is triggered by physical exertion, emotional stress, heavy meals, or cold...
Angina V: Nursing Management01:20

Angina V: Nursing Management

Angina, a symptom of myocardial ischemia, requires a structured nursing management approach to ensure effective care and prevent complications like myocardial infarction. Comprehensive nursing care involves assessing, diagnosing, planning, implementing interventions, and evaluating outcomes, all tailored to the individual patient's needs.Patient AssessmentNursing assessment begins with a detailed subjective evaluation of symptoms, which typically include chest pain or pressure radiating to the...
Antianginal Drugs: Nitrates and β-Blockers01:16

Antianginal Drugs: Nitrates and β-Blockers

In cardiovascular health, antianginal drugs combat angina pectoris — a condition marked by chest pain owing to diminished blood flow to the heart.
Organic nitrates,  such as nitroglycerin, play a pivotal role. Once metabolized, they liberate nitric oxide, a molecular marvel. Nitric oxide triggers guanylyl cyclase and augments cGMP production. This biochemical cascade orchestrates the relaxation of vascular smooth muscles, ushering in vasodilation and enhancing coronary blood flow. Administered...
Angina IV: Management01:26

Angina IV: Management

IntroductionThe management of angina requires a comprehensive approach that includes pharmacological therapies, medical procedures, and lifestyle modifications.Pharmacological TherapiesAntiplatelet agents, such as aspirin, clopidogrel, prasugrel, and ticagrelor, play a pivotal role in preventing thrombus formation in patients with angina. These medications inhibit platelet aggregation and reduce the likelihood of myocardial infarction and other cardiovascular events.Anticoagulants, including...

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Intracoronary Acetylcholine Provocation Testing for Assessment of Coronary Vasomotor Disorders
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Published on: August 18, 2016

Renal angina.

Stuart L Goldstein1, Lakhmir S Chawla

  • 1Department of Pediatrics, Renal Section, Baylor College of Medicine, Houston, Texas, USA.

Clinical Journal of the American Society of Nephrology : CJASN
|March 20, 2010
PubMed
Summary
This summary is machine-generated.

Serum creatinine is a late marker for acute kidney injury (AKI). Researchers seek an early biomarker, like troponin I for heart attacks, but need to define "renal angina" to guide its use and improve patient outcomes.

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Area of Science:

  • Nephrology
  • Critical Care Medicine
  • Biomarker Discovery

Background:

  • Serum creatinine elevations indicate kidney damage but are late markers for acute kidney injury (AKI).
  • The quest for an early AKI biomarker is likened to the search for troponin I in cardiology.
  • Unlike cardiac ischemia, AKI lacks a clear clinical equivalent to chest pain, hindering early suspicion.

Purpose of the Study:

  • To review adult and pediatric literature on acute kidney injury.
  • To propose a definition for a
  • renal anginal syndrome equivalent
  • to facilitate early AKI biomarker assessment and intervention.

Main Methods:

  • Comprehensive review of adult and pediatric acute kidney injury literature.
  • Analysis of the clinical utility of troponin I in myocardial infarction as a model for AKI biomarkers.

Main Results:

  • Current AKI biomarkers, including creatinine, are often detected late.
  • The absence of a "renal angina" equivalent limits the proactive use of potential early AKI biomarkers.
  • Defining a syndrome prompting biomarker testing is crucial for AKI management.

Conclusions:

  • Early detection of AKI is critical for improving patient outcomes.
  • Establishing a "renal angina" concept is essential for the effective implementation of novel AKI biomarkers.
  • This work aims to bridge the gap towards earlier AKI diagnosis and intervention.