Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Replication in Eukaryotes01:29

Replication in Eukaryotes

In eukaryotic cells, DNA replication is highly conserved and tightly regulated. Multiple linear chromosomes must be duplicated with high fidelity before cell division, so there are many proteins that fulfill specialized roles in the replication process. Replication occurs in three phases: initiation, elongation, and termination, and ends with two complete sets of chromosomes in the nucleus.
Many Proteins Orchestrate Replication at the Origin
Eukaryotic replication follows many of the same...
Replication in Eukaryotes02:31

Replication in Eukaryotes

Overview
Replication in Eukaryotes01:29

Replication in Eukaryotes

In eukaryotic cells, DNA replication is highly conserved and tightly regulated. Multiple linear chromosomes must be duplicated with high fidelity before cell division, so there are many proteins that fulfill specialized roles in the replication process. Replication occurs in three phases: initiation, elongation, and termination, and ends with two complete sets of chromosomes in the nucleus.
Many Proteins Orchestrate Replication at the Origin
Eukaryotic replication follows many of the same...
Replication in Eukaryotes02:31

Replication in Eukaryotes

Overview
Chromosome Structure02:40

Chromosome Structure

A functional eukaryotic chromosome must contain three elements: a centromere, telomeres, and numerous origins of replication.
The centromere is a DNA sequence that links sister chromatids. This is also where kinetochores, protein complexes to which spindle microtubules attach, are constructed after the chromosome is replicated. The kinetochores allow the spindle microtubules to move the chromosomes within the cell during cell division.
Telomeres consist of non-coding repetitive nucleotide...
The Replisome03:01

The Replisome

DNA replication is carried out by a large complex of proteins that act in a coordinated matter to achieve high-fidelity DNA replication. Together this complex is known as the DNA replication machinery or the replisome.
The synthesis of the leading and lagging strands is a highly coordinated process. To explain this, the “Trombone model” was proposed by Bruce Alberts in 1980. The DNA loop formation starts when a primer is synthesized on the parent lagging strand. The loop grows with the...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Structures of protein folding intermediates on the ribosome.

Nature structural & molecular biology·2026
Same author

Redirecting Excited-State Proton Transfer Through Supramolecular Polymerization in Nanoconfinement.

Angewandte Chemie (International ed. in English)·2026
Same author

Light and Dark Cycles Control the Structural Evolution of Photoresponsive Supramolecular Systems.

Angewandte Chemie (International ed. in English)·2026
Same author

What can a kinetic modelling approach reveal about the intricacies of mechanochemical kinetics?

Physical chemistry chemical physics : PCCP·2026
Same author

Unravelling key phenomena in ball milling reactions toward fundamental principles-a minireview tutorial.

Physical chemistry chemical physics : PCCP·2026
Same author

Condition-dependent amorphous protein agglomerates control cytoplasmic rheology.

Molecular cell·2026
Same journal

Erratum for the Research Article "Detecting supramolecular organic nanoparticles during heat wave".

Science (New York, N.Y.)·2026
Same journal

Local signals, systemic decline.

Science (New York, N.Y.)·2026
Same journal

The mechanics of liver regeneration.

Science (New York, N.Y.)·2026
Same journal

Computing in a memory with physics.

Science (New York, N.Y.)·2026
Same journal

Retraction.

Science (New York, N.Y.)·2026
Same journal

Making time.

Science (New York, N.Y.)·2026
See all related articles

Related Experiment Video

Updated: Jun 14, 2026

Hybrid Ensemble and Single-molecule Assay to Image the Motion of Fully Reconstituted CMG
10:11

Hybrid Ensemble and Single-molecule Assay to Image the Motion of Fully Reconstituted CMG

Published on: July 26, 2024

Mechanosensitive self-replication driven by self-organization.

Jacqui M A Carnall1, Christopher A Waudby, Ana M Belenguer

  • 1University of Cambridge, Department of Chemistry, Lensfield Road, Cambridge CB2 1EW, UK.

Science (New York, N.Y.)
|March 20, 2010
PubMed
Summary
This summary is machine-generated.

Two novel self-replicating molecules were discovered that form nanostructures. Mechanical forces like shaking or stirring influenced which molecule dominated, demonstrating their role in molecular evolution and synthesis.

More Related Videos

In Vitro Reconstitution of Self-Organizing Protein Patterns on Supported Lipid Bilayers
08:10

In Vitro Reconstitution of Self-Organizing Protein Patterns on Supported Lipid Bilayers

Published on: July 28, 2018

Self-Assembly of Microtubule Tactoids
08:49

Self-Assembly of Microtubule Tactoids

Published on: June 23, 2022

Related Experiment Videos

Last Updated: Jun 14, 2026

Hybrid Ensemble and Single-molecule Assay to Image the Motion of Fully Reconstituted CMG
10:11

Hybrid Ensemble and Single-molecule Assay to Image the Motion of Fully Reconstituted CMG

Published on: July 26, 2024

In Vitro Reconstitution of Self-Organizing Protein Patterns on Supported Lipid Bilayers
08:10

In Vitro Reconstitution of Self-Organizing Protein Patterns on Supported Lipid Bilayers

Published on: July 28, 2018

Self-Assembly of Microtubule Tactoids
08:49

Self-Assembly of Microtubule Tactoids

Published on: June 23, 2022

Area of Science:

  • * Origin of life studies
  • * Synthetic biology
  • * Supramolecular chemistry

Background:

  • * Self-replicating molecules are crucial for understanding life's origins.
  • * Identifying factors that influence replication dynamics is key.
  • * Synthetic self-replicators provide models for early life processes.

Purpose of the Study:

  • * To investigate factors influencing competition between self-replicating molecules.
  • * To explore the role of mechanical forces in molecular selection.
  • * To understand how nanostructure formation drives replication.

Main Methods:

  • * Creation of a small dynamic combinatorial library of peptide-derived macrocycles.
  • * Observation of two self-replicating macrocycles competing for a common feedstock.
  • * Analysis of replication driven by peptide assembly into beta-sheet stabilized fibers.
  • * Application of mechanical agitation (shaking vs. stirring) to the system.

Main Results:

  • * Two distinct self-replicating peptide-derived macrocycles were identified.
  • * Replication was dependent on the formation of self-assembling nanostructures (fibers).
  • * The dominance of one replicator over the other was significantly affected by mechanical forces (shaking/stirring).

Conclusions:

  • * Mechanical forces can act as a selection pressure in competing self-replicator systems.
  • * The outcome of covalent synthesis can be modulated by external physical factors.
  • * Nanostructure formation is a critical mechanism driving self-replication in this system.