Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Super-Cluster collimation for ultra-sensitive SPECT-PET: a simulation study.

Physics in medicine and biology·2025
Same author

Dual-photopeak joint image reconstruction for pinhole SPECT, PET and PET-SPECT.

Physics in medicine and biology·2025
Same author

Ultra-high energy spectral prompt PET.

Physics in medicine and biology·2025
Same author

Twisted clustered pinhole collimation for improved high-energy preclinical SPECT/PET.

Physics in medicine and biology·2024
Same author

NaI gamma camera performance for high energies: Effects of crystal thickness, photomultiplier tube geometry and light guide thickness.

Medical physics·2024
Same author

Evaluating the Targeting of a <i>Staphylococcus-aureus</i>-Infected Implant with a Radiolabeled Antibody In Vivo.

International journal of molecular sciences·2023
Same journal

Deep learning-based dose prediction to enhance planning efficiency in cervical brachytherapy with hybrid applicators.

Physics in medicine and biology·2026
Same journal

Corrigendum: Referenceless MR thermometry-a comparison of five methods (2017<i>Phys. Med. Biol</i>.<b>62</b>1-16).

Physics in medicine and biology·2026
Same journal

Corrigendum: Measured and Monte Carlo simulated electron backscatter to the monitor chamber for the varian TrueBeam linac (2016<i>Phys. Med. Biol</i>.<b>61</b>8779).

Physics in medicine and biology·2026
Same journal

Corrigendum: 3D range-modulator for scanned particle therapy: development, Monte Carlo simulations and experimental evaluation (2017<i>Phys. Med. Biol</i>.<b>62</b>7075).

Physics in medicine and biology·2026
Same journal

Recent progress in applications of computing to radiotherapy (ICCR 2016).

Physics in medicine and biology·2026
Same journal

Novel TMS coils designed using an inverse boundary element method.

Physics in medicine and biology·2026
See all related articles

Related Experiment Video

Updated: Jun 14, 2026

Whole-cell Super-Resolution Imaging via DNA-PAINT on a Spinning Disk Confocal with Optical Photon Reassignment
07:12

Whole-cell Super-Resolution Imaging via DNA-PAINT on a Spinning Disk Confocal with Optical Photon Reassignment

Published on: January 6, 2026

Pixel-based subsets for rapid multi-pinhole SPECT reconstruction.

Woutjan Branderhorst1, Brendan Vastenhouw, Freek J Beekman

  • 1Image Sciences Institute, University Medical Center Utrecht, The Netherlands.

Physics in Medicine and Biology
|March 20, 2010
PubMed
Summary
This summary is machine-generated.

Pixel-based ordered subset expectation maximization (POSEM) improves SPECT imaging accuracy. This novel method allows for significantly higher acceleration factors compared to traditional OSEM, enabling faster and more precise image reconstruction.

More Related Videos

High-plex Imaging using Spectral Confocal Microscopy to Minimize Non-specific Tissue Fluorescence
10:28

High-plex Imaging using Spectral Confocal Microscopy to Minimize Non-specific Tissue Fluorescence

Published on: October 28, 2025

Digital Inline Holographic Microscopy (DIHM) of Weakly-scattering Subjects
10:16

Digital Inline Holographic Microscopy (DIHM) of Weakly-scattering Subjects

Published on: February 8, 2014

Related Experiment Videos

Last Updated: Jun 14, 2026

Whole-cell Super-Resolution Imaging via DNA-PAINT on a Spinning Disk Confocal with Optical Photon Reassignment
07:12

Whole-cell Super-Resolution Imaging via DNA-PAINT on a Spinning Disk Confocal with Optical Photon Reassignment

Published on: January 6, 2026

High-plex Imaging using Spectral Confocal Microscopy to Minimize Non-specific Tissue Fluorescence
10:28

High-plex Imaging using Spectral Confocal Microscopy to Minimize Non-specific Tissue Fluorescence

Published on: October 28, 2025

Digital Inline Holographic Microscopy (DIHM) of Weakly-scattering Subjects
10:16

Digital Inline Holographic Microscopy (DIHM) of Weakly-scattering Subjects

Published on: February 8, 2014

Area of Science:

  • Medical Imaging
  • Nuclear Medicine
  • Computational Science

Background:

  • Block-iterative methods like ordered subset expectation maximization (OSEM) accelerate image reconstruction in single photon emission computed tomography (SPECT).
  • OSEM's speed-up is proportional to the number of subsets, but higher factors can lead to deviations from maximum likelihood expectation maximization (MLEM) solutions.
  • Traditional OSEM subsetting, using few projection views, results in inaccurate reconstructions for multi-pinhole SPECT, even at moderate acceleration.

Purpose of the Study:

  • To introduce and validate a novel image reconstruction algorithm, pixel-based ordered subset expectation maximization (POSEM), for multi-pinhole SPECT.
  • To compare the performance of POSEM against traditional OSEM and MLEM in terms of accuracy and achievable acceleration factors.
  • To demonstrate the effectiveness of POSEM for various SPECT imaging applications.

Main Methods:

  • Developed POSEM, an alternative subsetting strategy where pixels are regularly spread across projections and spatially separated.
  • Validated POSEM using data from a focusing multi-pinhole SPECT system.
  • Compared POSEM with OSEM and MLEM reconstructions for a rat bone scan, a mouse myocardial perfusion scan, and a Defrise phantom.

Main Results:

  • POSEM enables significantly higher acceleration factors compared to traditional OSEM, often by an order of magnitude.
  • Reconstructions using POSEM demonstrated improved accuracy, especially at high acceleration rates.
  • The method proved effective across different SPECT imaging scenarios, including total body bone scans and myocardial perfusion imaging.

Conclusions:

  • POSEM offers a substantial improvement in accelerating multi-pinhole SPECT image reconstruction while maintaining accuracy.
  • The pixel-based subsetting approach overcomes limitations of traditional OSEM, allowing for greater speed-up.
  • POSEM represents a promising advancement for efficient and accurate SPECT imaging.