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Published on: September 15, 2023
N-acetylcysteine does not prevent renal dysfunction after off-pump coronary artery bypass surgery
Apoorva Prasad1, Sanjaykumar Banakal, Kanchi Muralidhar
1Department of Anaesthesiology, Narayana Hrudayalaya Institute of Medical Sciences, Bommasandra Industrial Area, Bangalore, India. docapoorvap@gmail.com
Background And Objective:
Coronary artery bypass graft surgery in high-risk patients may be associated with postoperative renal dysfunction. N-Acetylcysteine is a powerful antioxidant and has been used to prevent contrast-induced renal dysfunction. The efficacy of N-acetylcysteine in preventing postoperative renal dysfunction following off-pump coronary artery bypass graft surgery was studied.
Methods:
A prospective, randomized, controlled study was conducted in patients undergoing off-pump coronary artery bypass graft. The study group (37 patients) received N-acetylcysteine in the perioperative period, whereas the control group (37 patients) did not. The data obtained were analysed using the independent sample t-test (Student's t-test) and χ-test.
Results:
There was no significant difference in the incidence of renal dysfunction between the two groups. Three patients (8.6%) in the N-acetylcysteine group and four (11.4%) in the control group developed renal dysfunction (P value was 1.00).
Conclusion:
N-Acetylcysteine does not have any beneficial effect on renal function in high-risk patients undergoing off-pump coronary artery bypass graft.
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