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Related Experiment Video

Updated: Jun 14, 2026

Highly Multiplexed, Super-resolution Imaging of T Cells Using madSTORM

Highly Multiplexed, Super-resolution Imaging of T Cells Using madSTORM

Published on: June 24, 2017

Nano-imaging with Storm.

Xiaowei Zhuang¹

¹Department of Chemistry and Chemical Biology, and the Department of Physics, Howard Hughes Medical Institute, Harvard University, Cambridge, Massachusetts 02138, USA. zhuang@chemistry.harvard.edu.

Nature Photonics

|March 20, 2010

Summary

This summary is machine-generated.

Multicolour, three-dimensional stochastic optical reconstruction microscopy (STORM) allows imaging of cellular structures at near molecular resolution. This advanced technique provides unprecedented detail for biological research.

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Related Experiment Videos

Last Updated: Jun 14, 2026

Highly Multiplexed, Super-resolution Imaging of T Cells Using madSTORM

Highly Multiplexed, Super-resolution Imaging of T Cells Using madSTORM

Published on: June 24, 2017

Imaging Intermediate Filaments and Microtubules with 2-dimensional Direct Stochastic Optical Reconstruction Microscopy

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Published on: March 6, 2018

Direct Stochastic Optical Reconstruction Microscopy of Extracellular Vesicles in Three Dimensions

Direct Stochastic Optical Reconstruction Microscopy of Extracellular Vesicles in Three Dimensions

Published on: August 26, 2021

Area of Science:

Biophysics
Cell Biology
Microscopy

Background:

Understanding cellular structures is crucial for biological research.
Traditional microscopy techniques have limitations in resolving fine cellular details.

Purpose of the Study:

To introduce and demonstrate the capabilities of multicolour, three-dimensional stochastic optical reconstruction microscopy (3D STORM).
To showcase the near molecular-scale resolution achievable with 3D STORM for imaging cellular structures.

Main Methods:

Utilizing multicolour, three-dimensional stochastic optical reconstruction microscopy (3D STORM).
Applying advanced imaging techniques to achieve high-resolution visualization of cellular components.

Main Results:

Achieved near molecular-scale resolution in imaging cellular structures.
Successfully visualized complex cellular architectures with unprecedented detail.

Conclusions:

Multicolour 3D STORM is a powerful tool for high-resolution cellular imaging.
This technique significantly advances the ability to study cellular structures at the molecular level.