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Privileged scaffolds for library design and drug discovery
Matthew E Welsch1, Scott A Snyder, Brent R Stockwell
1Columbia University, Department of Chemistry, Havemeyer Hall, MC 3129, 3000 Broadway, New York, NY 10027, USA.
None:
This review explores the concept of using privileged scaffolds to identify biologically active compounds through building chemical libraries. We hope to accomplish three main objectives: to provide one of the most comprehensive listings of privileged scaffolds; to reveal through four selected examples the present state of the art in privileged scaffold library synthesis (in hopes of inspiring new and even more creative approaches); and also to offer some thoughts on how new privileged scaffolds might be identified and exploited.
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