Related Experiment Video
Updated: Jun 14, 2026

Tissue-specific miRNA Expression Profiling in Mouse Heart Sections Using In Situ Hybridization
Published on: September 15, 2018
MicroRNA dysregulation in psychiatric disease
Brooke H Miller1, Claes Wahlestedt
1Department of Neuroscience, Scripps Florida, Jupiter, FL 33458, USA.
None:
MicroRNAs (miRNAs) are small regulatory RNAs that individually regulate up to several hundred genes, and collectively may regulate as much as two-thirds of the transcriptome. Recent evidence supports a role for miRNA dysregulation in psychiatric and neurological disorders, including schizophrenia, bipolar disorder, and autism. Small changes in miRNA expression can fine-tune the expression of multiple genes within a biological network, suggesting that miRNA dysregulation may underlie many of the molecular changes observed in psychiatric disease, and that therapeutic regulation of miRNA levels may represent a novel treatment option.
Related Concept Videos
MicroRNAs
MicroRNAs
MicroRNAs
Gut-Brain Axis
Circadian Rhythms and Gene Regulation

