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A Proteoliposome-Based Efflux Assay to Determine Single-molecule Properties of Cl- Channels and Transporters
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Antiport mechanism for Cl(-)/H(+) in ClC-ec1 from normal-mode analysis.

Gennady V Miloshevsky1, Ahmed Hassanein, Peter C Jordan

  • 1School of Nuclear Engineering, Purdue University, West Lafayette, Indiana, USA.

Biophysical Journal
|March 23, 2010
PubMed
Summary

The ClC-ec1 antiporter uses a unique mechanism for chloride and proton exchange, involving simultaneous pore conformational changes. This finding offers insights into related transporters and channels in eukaryotes.

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