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[Age of menopause in patients with differentiated thyroid cancer treated with radioiodine]
Juan Manuel García-Quirós Muñoz1, Tomás Martín Hernández, Alberto Torres Cuadro
1Servicio de Endocrinología y Nutrición, Hospital Universitario Virgen Macarena, Sevilla, España.
Introduction:
Differentiated thyroid cancer (DTC) is an increasingly frequent endocrinological disease. Radioiodine is a key component of treatment.
Objective:
To analyze the effects of I(131) therapy on ovarian and reproductive function.
Material And Methods:
We retrospectively analyzed data from 202 women treated with radioiodine for DTC in our service from 1985-2008. Data on age at menopause in patients and their mothers and sisters, menstrual history, fertility and neonatal abnormalities were collected.
Results:
Menopause occurred in 34 patients at follow-up. The mean age at menopause in patients was 49.94+/-3.45 while that in their mothers and sisters was 49.20+/-5.37 and 48.73+/-3.74 years, respectively. Three patients had transient amenorrhea. No infertility or neonatal alterations were found.
Conclusions:
In our series, menopause did not occur earlier in patients than in their first degree relatives. No significant alterations in neonatal health, fertility or menstruation were found.
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