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Updated: Jun 14, 2026
06:49
The Rodent Model of Nonarteritic Anterior Ischemic Optic Neuropathy (rNAION)
Published on: November 20, 2016
Choroidal lymphoma masquerading as anterior ischemic optic neuropathy
Ali Tavallali1, Carol L Shields, Carlos Bianciotto
1Ocular Oncology Service, Wills Eye Institute, Thomas Jefferson University, Philadelphia, PA 19107, USA.
European Journal of Ophthalmology
|March 23, 2010
Summary
Bilateral uveal lymphoma can mimic nonarteritic anterior ischemic optic neuropathy (NAION) and choroidal metastasis. Prompt diagnosis through imaging and biopsy is crucial for appropriate treatment of this rare condition.
Area of Science:
- Ophthalmology
- Oncology
- Diagnostic Imaging
Background:
- Nonarteritic anterior ischemic optic neuropathy (NAION) is a common cause of optic nerve dysfunction.
- Uveal lymphoma is a rare malignancy affecting the eye.
Observation:
- A 60-year-old man presented with symptoms suggestive of NAION.
- Initial treatment for presumed NAION with oral steroids was ineffective.
- Ocular imaging revealed bilateral choroidal infiltrative processes.
Findings:
- Fine needle aspiration biopsy confirmed bilateral uveal lymphoma.
- The lymphoma presented as atypical lymphocytes without necrosis.
- Ultrasound showed an acoustically hollow tumor in the left choroid.
Implications:
- Choroidal lymphoma can present with diverse clinical features, mimicking other ocular conditions.
- Accurate diagnosis requires a combination of clinical evaluation, advanced imaging (MRI, ultrasound), and histopathology.
- Early detection and treatment of uveal lymphoma are essential for visual preservation and systemic management.
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