Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Tumor Progression02:07

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Decreased HER2 expression in endometrial cancer following anti-HER2 therapy.

The Journal of pathology·2023
Same author

Nonlobular Invasive Breast Carcinomas with Biallelic Pathogenic CDH1 Somatic Alterations: A Histologic, Immunophenotypic, and Genomic Characterization.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc·2023
Same author

Chronic Interferon Stimulated Gene Transcription Promotes Oncogene Induced Breast Cancer.

bioRxiv : the preprint server for biology·2023
Same author

Somatic estrogen receptor α mutations that induce dimerization promote receptor activity and breast cancer proliferation.

The Journal of clinical investigation·2023
Same author

Large language models should be used as scientific reasoning engines, not knowledge databases.

Nature medicine·2023
Same author

ctDNA-based detection of molecular residual disease in stage I-III non-small cell lung cancer patients treated with definitive radiotherapy.

Frontiers in oncology·2023
Same journal

Update on the molecular pathology of the distinctive giant cell, fibro-osseous and bone forming lesions of the jaws.

Seminars in diagnostic pathology·2026
Same journal

Update on the molecular pathology and classification of odontogenic cysts and tumours.

Seminars in diagnostic pathology·2026
Same journal

MDM2 gene amplification in surgical pathology: biology, diagnostic utility, and clinical relevance in the modern era.

Seminars in diagnostic pathology·2026
Same journal

When three negatives equal a positive: Molecular updates of triple-negative breast carcinomas with favorable prognoses.

Seminars in diagnostic pathology·2026
Same journal

Old school, new insight: Revisiting histomorphology in the modern era of prostate cancer risk stratification.

Seminars in diagnostic pathology·2026
Same journal

Recent advances in genetic predisposition to primary testicular tumors.

Seminars in diagnostic pathology·2026
See all related articles

Related Experiment Video

Updated: Jun 14, 2026

Changes in Mammary Gland Morphology and Breast Cancer Risk in Rats
09:36

Changes in Mammary Gland Morphology and Breast Cancer Risk in Rats

Published on: October 16, 2010

Breast pathology: beyond morphology.

Peter T Simpson1, Jorge S Reis-Filho, Sunil R Lakhani

  • 1University of Queensland Centre for Clinical Research, The Royal Brisbane and Women's Hospital, Brisbane, QLD, Australia.

Seminars in Diagnostic Pathology
|March 24, 2010
PubMed
Summary
This summary is machine-generated.

Breast cancer classification is evolving from morphology to molecular methods for better patient prognostication and targeted therapies. Combining these approaches promises to advance breast cancer histopathology and improve patient care.

More Related Videos

Long-term Culture of Human Breast Cancer Specimens and Their Analysis Using Optical Projection Tomography
10:10

Long-term Culture of Human Breast Cancer Specimens and Their Analysis Using Optical Projection Tomography

Published on: July 29, 2011

A Multimodal Imaging Framework to Advance Phenotyping of Living Label-free Breast Cancer Cells
10:37

A Multimodal Imaging Framework to Advance Phenotyping of Living Label-free Breast Cancer Cells

Published on: August 22, 2025

Related Experiment Videos

Last Updated: Jun 14, 2026

Changes in Mammary Gland Morphology and Breast Cancer Risk in Rats
09:36

Changes in Mammary Gland Morphology and Breast Cancer Risk in Rats

Published on: October 16, 2010

Long-term Culture of Human Breast Cancer Specimens and Their Analysis Using Optical Projection Tomography
10:10

Long-term Culture of Human Breast Cancer Specimens and Their Analysis Using Optical Projection Tomography

Published on: July 29, 2011

A Multimodal Imaging Framework to Advance Phenotyping of Living Label-free Breast Cancer Cells
10:37

A Multimodal Imaging Framework to Advance Phenotyping of Living Label-free Breast Cancer Cells

Published on: August 22, 2025

Area of Science:

  • Oncology
  • Pathology
  • Genomics

Background:

  • Breast cancer is a complex disease requiring sophisticated classification systems.
  • Morphological classification by pathologists provides prognostic and predictive information for patient management.
  • Professor Azzopardi's work significantly advanced breast disease classification.

Purpose of the Study:

  • To review the current state of breast cancer classification.
  • To highlight the limitations of morphological classification.
  • To explore the potential of emerging molecular methods in breast cancer diagnosis and treatment.

Main Methods:

  • Review of existing literature on breast cancer classification.
  • Discussion of the evolution from morphological to molecular techniques.
  • Analysis of the potential integration of new molecular data with traditional histopathology.

Main Results:

  • Morphological classification, while valuable, has inherent limitations in fully capturing breast cancer heterogeneity.
  • Molecular methods offer promise for a more refined biological understanding.
  • New molecular techniques may yield improved biomarkers for prognostication and therapeutic targets.

Conclusions:

  • A symbiotic approach integrating morphology and molecular techniques is anticipated to enhance traditional histopathology.
  • This integration holds the potential to significantly improve the care of breast cancer patients.
  • Further research is needed to fully realize the value of molecular methods alongside established morphological assessments.