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Related Experiment Video

Updated: Jun 14, 2026

Perceptual and Category Processing of the Uncanny Valley Hypothesis' Dimension of Human Likeness: Some Methodological Issues
07:34

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Published on: June 3, 2013

Hyperfamiliarity for faces.

O Devinsky1, L Davachi, C Santchi

  • 1Department of Neurology, NYU Langone School of Medicine, New York, NY, USA. od4@nyu.edu

Neurology
|March 24, 2010
PubMed
Summary
This summary is machine-generated.

Hyperfamiliarity for faces (HFF) is a syndrome linked to epilepsy, often involving left temporal lobe abnormalities. This condition, though rarely diagnosed, may be more common than reported cases suggest.

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Area of Science:

  • Neurology
  • Neuroscience
  • Epileptology

Background:

  • Hyperfamiliarity for faces (HFF) is a rare syndrome characterized by an excessive sense of familiarity with unfamiliar faces.
  • Understanding the underlying pathophysiology of HFF is crucial for diagnosis and management.

Observation:

  • This study reports 4 new cases of HFF and reviews 5 previously documented cases.
  • Pathologic findings in 3 of the 4 new cases were most extensive in the left temporal lobe.
  • HFF onset was associated with seizures in 6 of the 9 total cases, occurring postictally or during seizure activity.

Findings:

  • All 9 cases involved adults with epilepsy; HFF symptoms varied in duration from seconds to over 7 years.
  • Lesions, when present, were frequently left-sided and involved the temporal lobe, but HFF duration was not linked to lesion extent.
  • While postictal Todd paralysis may explain some cases, the mechanism for persistent HFF remains uncertain.

Implications:

  • HFF is a visual and face-specific syndrome associated with diverse neurological findings, including structural and functional abnormalities.
  • The consistent presence of epilepsy in HFF cases suggests a pathophysiological link, though the exact relationship varies.
  • HFF may be significantly underdiagnosed, highlighting the need for increased clinical awareness.