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Statin users without an APOE-epsilon4 allele have increased insulin resistance
Brian T VanFossen1, G Stennis Watson, Laura D Baker
1GRECC, VA Puget Sound Health Care System, Seattle, WA 98108, USA.
Abstract:
The present study examined the relationships among statin use, APOE genotype, and insulin resistance as measured by the homeostasis model assessment of insulin resistance (HOMA-IR) in healthy older adults. APOE epsilon4- (i.e., not having an epsilon4 allele) statin users had higher HOMA-IR values compared with epsilon4+/statin users (p=0.0169), and with non-users who were epsilon4- (p=0.0003) or epsilon4+ (p=0.0006). These results suggest that statin use may modulate insulin levels for individuals without an APOE epsilon4 allele.
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