Related Experiment Video
Updated: Jun 14, 2026

Depolymerizable Olefinic Polymers Based on Fused-Ring Cyclooctene Monomers
Published on: December 16, 2022
Marrying click chemistry with polymerization: expanding the scope of polymeric materials
Patricia L Golas1, Krzysztof Matyjaszewski
1Department of Chemistry, Carnegie Mellon University, 4400 Fifth Avenue, Pittsburgh, Pennsylvania 15213, USA.
Abstract:
Click chemistry constitutes a class of reactions broadly characterized by efficiency, selectivity, and tolerance to a variety of solvents and functional groups. By far the most widely utilized of these efficient transformation reactions is the Cu(I)-catalyzed azide-alkyne cycloaddition. This reaction has been creatively employed to facilitate the preparation of complex macromolecules, such as multiblock copolymers, shell or core cross-linked micelles, and dendrimers. This critical review highlights the application of click chemistry, in particular the Cu(I)-catalyzed azide-alkyne cycloaddition, to the synthesis of a wide variety of new materials with possible uses as drug delivery agents, tissue engineering scaffolds, and dispersible nanomaterials (83 references).
Related Concept Videos
Polymers
Polymers
Polymers
Anionic Chain-Growth Polymerization: Overview
Cationic Chain-Growth Polymerization: Mechanism
Step-Growth Polymerization: Overview
Many natural and synthetic polymers are produced by...

