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[Virus inactivation by hydrogen peroxide].

R Mentel', R Shirrmakher, A Kevich

    Voprosy Virusologii
    |November 1, 1977
    PubMed
    Summary
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    Hydrogen peroxide (H2O2) effectively inactivates various viruses like coronaviruses and influenza viruses within minutes. This study demonstrates H2O2

    Area of Science:

    • Virology
    • Microbiology
    • Biochemistry

    Background:

    • Viruses pose significant public health challenges.
    • Effective and rapid inactivation methods are crucial for disinfection and safety.

    Purpose of the Study:

    • To evaluate the efficacy of hydrogen peroxide (H2O2) in inactivating a range of common viruses.
    • To determine the optimal concentration and exposure time for H2O2-mediated virus inactivation.

    Main Methods:

    • In vitro study exposing various viruses to different H2O2 concentrations and exposure times.
    • Viruses tested include adenovirus, adenoassociated virus, rhinoviruses, myxoviruses, influenza A and B, respiratory syncytial virus, and coronavirus.

    Main Results:

    • A 3% concentration of H2O2 inactivated all tested viruses within 1 to 30 minutes.

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  • Coronaviruses and influenza viruses showed the highest sensitivity to H2O2.
  • Reoviruses, adenoviruses, and adenoassociated viruses exhibited relative stability.

    • Conclusions:

    • Hydrogen peroxide is a potent and convenient agent for rapid virus inactivation.
    • H2O2 demonstrates broad-spectrum antiviral activity, making it valuable for disinfection protocols.