Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Pharmacologic study of clofelin].

B A Medvedev

    Farmakologiia I Toksikologiia
    |May 1, 1977
    PubMed
    Summary
    This summary is machine-generated.

    Clofelin, a clonidine analog, was studied for its pharmacological effects. This drug lowers blood pressure and heart rate in animals, showing it is identical to foreign clonidine medications.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    [Isolation of highly pathogenic avian influenza (HPAI) A/5H5N1 strains from wild birds in the epizootic outbreak on the Ubsu-Nur Lake (June 2006) and their incorporation to the Russian Federation State Collection of viruses (July 3, 2006)].

    Voprosy virusologii·2007
    Same author

    [Influence of antidepressants on the hypotensive effect of clofeline in rats].

    Farmakologiia i toksikologiia·1980
    Same author

    [Pharmacological properties and clinical use of clofelin].

    Klinicheskaia meditsina·1979
    Same author

    [The pharmacologic properties of beta-(indolinyl-l)ethylguanidine sulfate].

    Farmakologiia i toksikologiia·1973
    Same author

    [Pharmacological properties of 3-methyl-3,9-diazabicyclo(3,3,1) nonane derivatives of 2-chlorophenothiazine].

    Farmakologiia i toksikologiia·1972
    Same author

    [Ganglioblocking and curariform properties of haloidmethylates 1-(omega-dialkylaminoalykyl)-3-benzylquinuclidine hallogenoids].

    Farmakologiia i toksikologiia·1968

    Area of Science:

    • Pharmacology
    • Cardiovascular Research

    Background:

    • Clofelin (2-(2,6-dichlorphenylamino)-2-imidasoline) is an analog of clonidine.
    • Clonidine is a widely used antihypertensive medication.

    Purpose of the Study:

    • To conduct a pharmacological study of Clofelin.
    • To compare the effects of Clofelin with foreign-made clonidine drugs.

    Main Methods:

    • Pharmacological assessment in animal models.
    • Observation of arterial pressure, cardiac contraction frequency, and motor activity.
    • Evaluation of adrenomimetic effects.

    Main Results:

    • Clofelin initially raises, then lowers arterial pressure.
    • The drug reduces cardiac contraction frequency and reflex hypertension.

    Related Experiment Videos

  • Low doses of Clofelin cause decreased motor activity and adrenomimetic symptoms.
  • Hypertension is linked to peripheral alpha-adrenomimetic action; hypotension to central action.

    • Conclusions:

    • Clofelin exhibits pharmacological properties similar to clonidine.
    • The study confirms Clofelin's identity with corresponding foreign drugs.