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Acalculous candidal cholecystitis after pediatric renal transplant

Jennifer Grosser1, Harvey Solomon, Cirilo Sotelo-Avila

  • 1Department of Surgery, Saint Louis University Hospital, St. Louis, MO 63110, USA. jgrosser@slu.edu

Pediatric Transplantation
|March 25, 2010
PubMed

Insights

This study details a rare case of acalculous cholecystitis caused by Candida in a pediatric renal transplant patient. It highlights the importance of considering fungal infections in post-operative biliary complications.

Area of Science:

  • Medical Mycology
  • Transplant Surgery
  • Gastroenterology

Background:

  • Acalculous cholecystitis (AAC) is uncommon, particularly in non-critically ill patients.
  • Candida species are known pathogens but rarely cause AAC.
  • Renal transplant recipients are immunocompromised, increasing susceptibility to opportunistic infections.

Observation:

  • An 18-month-old renal transplant patient developed AAC post-operatively.
  • The patient's AAC was attributed solely to Candida, without biliary calculi or other pathogens.
  • This case represents a unique presentation of candidal AAC.

Findings:

  • The study presents the first documented case of Candida-induced AAC without confounding factors.
  • Literature review on candidal AAC, diagnosis, treatment, and mortality was conducted.
  • Key diagnostic and therapeutic strategies for candidal AAC were discussed.

Implications:

  • Highlights the need to consider Candida as a causative agent for AAC in immunocompromised patients, especially post-transplant.
  • Emphasizes the importance of early diagnosis and targeted antifungal therapy.
  • Contributes to understanding the clinical spectrum and management of invasive fungal infections in transplant recipients.

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