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Automated, Quantitative Cognitive/Behavioral Screening of Mice: For Genetics, Pharmacology, Animal Cognition and Undergraduate Instruction

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[Construction of a system for proper TS-1 application].

Sayaka Azuma¹, Shigefumi Morimoto, Kunihiko Kagawa

¹Dept. of Pharmacy, National Hospital Organization, Osaka Minami Medical Center.

Gan to Kagaku Ryoho. Cancer & Chemotherapy

|March 25, 2010

Summary

A new computer system helps pharmacists monitor kidney function for patients taking the anti-tumor drug TS-1. This system identifies patients with impaired renal function, preventing potential side effects from the drug's metabolite, 5-chloro-2, 4-dihydroxypyridine (CDHP).

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Area of Science:

Oncology
Pharmacology
Nephrology

Context:

TS-1, an oral anti-tumor medication, contains 5-chloro-2, 4-dihydroxypyridine (CDHP), primarily excreted via urine.
Elevated CDHP levels in patients with renal impairment correlate with increased TS-1 side effects.
Real-time monitoring of renal function is crucial for safe TS-1 administration.

Purpose:

To develop and implement a computer-aided system for pharmacists to monitor patients' creatinine clearance (Ccr) when prescribing TS-1.
To proactively identify patients with decreased renal function who may require dosage adjustments.
To investigate potential contributing factors to adverse events in patients with varying degrees of renal impairment.

Summary:

A computer system was developed to display serum creatinine levels and calculate Ccr for patients receiving TS-1.
The system identified two cases where TS-1 was prescribed despite reduced Ccr, necessitating dosage review.
One patient with Ccr < 30 mL/min/m2 showed altered drug pharmacokinetics; another with Ccr 50 mL/min/m2 experienced jaundice, prompting further investigation.

Impact:

The system provides pharmacists with real-time data on patient dosage and renal function, facilitating safer drug management.
It enables timely identification of patients at risk for drug accumulation and adverse events due to renal dysfunction.
The system's adaptability allows for application to other medications prone to accumulation in patients with impaired kidney function.