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Updated: Jun 14, 2026
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High-Resolution Cardiac Positron Emission Tomography/Computed Tomography for Small Animals
Published on: December 16, 2022
Dynamic myocardial stress perfusion imaging using fast dual-source CT with alternating table positions: initial
Fabian Bamberg1, Ernst Klotz, Thomas Flohr
1Department of Clinical Radiology, Ludwig Maximilians University, Klinikum Grosshadern, Munich, Germany. fabian.bamberg@med.uni-muenchen.de
European Radiology
|March 25, 2010
Summary
Model-based computed tomography (CT) can determine regional myocardial blood flow (MBF) in vivo. This method quantifies differences in MBF, potentially assessing coronary artery disease severity.
Area of Science:
- Cardiovascular imaging
- Medical physics
- Radiology
Background:
- Assessing regional myocardial blood flow (MBF) is crucial for diagnosing coronary artery disease (CAD).
- Computed tomography (CT) offers potential for non-invasive assessment of myocardial perfusion.
Observation:
- A dynamic dual-source CT protocol was employed, utilizing ECG-triggered end-systolic timing and merged reconstructions.
- Parametric deconvolution techniques were applied to time-attenuation curves (TACs) to derive MBF.
Findings:
- The study demonstrated in vivo applicability of model-based MBF determination using CT.
- Quantitative MBF differences were observed between ischemic and non-ischemic myocardial regions.
Implications:
- This approach may enable parallel assessment of coronary artery anatomy and hemodynamic significance.
- Further feasibility studies are warranted to confirm the clinical utility of CT-based MBF quantification.
