Metastasis after resection of huge primary pericardial pleomorphic liposarcoma with cardiopulmonary bypass

Liposarcoma is the most commonly diagnosed soft tissue sarcoma in adults and occurs predominantly in the lower limbs or retroperitoneal area. However, of the five types of liposarcoma, primary pleomorphic liposarcoma originating in the pericardium is extremely rare. Because of its location in the anterior mediastinum, life-threatening symptoms and signs frequently require urgent surgery with extracorporeal circulation. However, there is no previous report warning of the possible dangerous effect of cardiopulmonary bypass. We present a rare case of huge malignant primary pericardial pleomorphic liposarcoma with early postoperative multiple metastases which may be due to cardiopulmonary bypass.