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Chemical Triphosphorylation of Oligonucleotides
Published on: June 2, 2022
Phosphoramidites: privileged ligands in asymmetric catalysis
Johannes F Teichert1, Ben L Feringa
1Stratingh Institute for Chemistry and Center for Systems Chemistry, University of Groningen, Nijenborgh 4, 9747 AG, Groningen, The Netherlands.
Angewandte Chemie (International Ed. in English)
|March 25, 2010
Summary
Chiral phosphoramidite ligands enable precise control in asymmetric catalysis, facilitating the creation of complex molecules. This review highlights their recent advances in forming crucial carbon-carbon and carbon-heteroatom bonds.
Area of Science:
- Organic Chemistry
- Catalysis
- Synthetic Chemistry
Background:
- Asymmetric catalysis using transition-metal complexes is fundamental to modern stereoselective synthesis.
- Chiral ligands are crucial for controlling regio-, diastereoselectivity, and enantioselectivity in these reactions.
Purpose of the Study:
- To review recent advancements in asymmetric catalysis employing phosphoramidite ligands.
- To focus on the application of phosphoramidites in carbon-carbon and carbon-heteroatom bond formation.
Main Methods:
- Discussion of recent developments in asymmetric catalysis.
- Focus on phosphoramidites as versatile chiral ligands.
- Analysis of their role in stereoselective transformations.
Main Results:
- Phosphoramidites offer a modular and accessible platform for ligand design.
- Their structure allows for fine-tuning and library formation for specific catalytic reactions.
- Exceptional stereocontrol is frequently achieved with phosphoramidite ligands.
Conclusions:
- Phosphoramidites are highly effective chiral ligands in asymmetric catalysis.
- Their monodentate nature is advantageous for combinatorial approaches.
- Recent developments showcase their utility in key bond-forming reactions.
![Mizoroki-Heck Cross-coupling Reactions Catalyzed by Dichloro{bis[1,1',1''-(phosphinetriyl)tripiperidine]}palladium Under Mild Reaction Conditions](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F51444.jpg&w=3840&q=50)
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