Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Improving Translational Accuracy02:07

Improving Translational Accuracy

Base complementarity between the three base pairs of mRNA codon and the tRNA anticodon is not a failsafe mechanism. Inaccuracies can range from a single mismatch to no correct base pairing at all. The free energy difference between the correct and nearly correct base pairs can be as small as 3 kcal/ mol. With complementarity being the only proofreading step, the estimated error frequency would be one wrong amino acid in every 100 amino acids incorporated. However, error frequencies observed in...
Improving Translational Accuracy02:07

Improving Translational Accuracy

Base complementarity between the three base pairs of mRNA codon and the tRNA anticodon is not a failsafe mechanism. Inaccuracies can range from a single mismatch to no correct base pairing at all. The free energy difference between the correct and nearly correct base pairs can be as small as 3 kcal/ mol. With complementarity being the only proofreading step, the estimated error frequency would be one wrong amino acid in every 100 amino acids incorporated. However, error frequencies observed in...
Translation01:31

Translation

Translation is the process of synthesizing proteins from the genetic information carried by messenger RNA (mRNA). Following transcription, it constitutes the final step in the expression of genes. This process is carried out by ribosomes, complexes of protein and specialized RNA molecules. Ribosomes, transfer RNA (tRNA), and other proteins produce a chain of amino acids—the polypeptide—as the end product of translation.
Translation Produces the Building Blocks of Life
Proteins are called the...
Translation01:31

Translation

Lesson: Translation
Translation is the process of synthesizing proteins from the genetic information carried by messenger RNA (mRNA). Following transcription, it constitutes the final step in the expression of genes. This process is carried out by ribosomes, complexes of protein and specialized RNA molecules. Ribosomes, transfer RNA (tRNA), and other proteins produce a chain of amino acids—the polypeptide—as the end product of translation.
Translation Produces the Building Blocks of Life
Translation01:31

Translation

Lesson: Translation
Translation is the process of synthesizing proteins from the genetic information carried by messenger RNA (mRNA). Following transcription, it constitutes the final step in the expression of genes. This process is carried out by ribosomes, complexes of protein and specialized RNA molecules. Ribosomes, transfer RNA (tRNA), and other proteins produce a chain of amino acids—the polypeptide—as the end product of translation.
Translation Produces the Building Blocks of Life
Translation01:31

Translation

Lesson: Translation
Translation is the process of synthesizing proteins from the genetic information carried by messenger RNA (mRNA). Following transcription, it constitutes the final step in the expression of genes. This process is carried out by ribosomes, complexes of protein and specialized RNA molecules. Ribosomes, transfer RNA (tRNA), and other proteins produce a chain of amino acids—the polypeptide—as the end product of translation.
Translation Produces the Building Blocks of Life

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Nurses carry substantial student loans: health care workforce implications.

Health affairs scholar·2026
Same author

RN Reflections: Lessons Learned, Recommendations, and Pearls of Wisdom in Caring for the COVID-19 Population.

Western journal of nursing research·2025
Same author

Nurse-reported workplace violent events: Results from a repeated statewide survey.

Nursing outlook·2024
Same author

Changes in Registered Nurse Employment Plans and Workplace Assessments.

JAMA network open·2024
Same author

Atrial Fibrillation and Older Age Predict Serum Brain-Derived Neurotrophic Factor Levels Among Patients With Heart Failure.

The Journal of cardiovascular nursing·2024
Same author

Registered Nurses' Well-Being, Michigan, 2022.

American journal of public health·2024
Same journal

Moral Distress in Nurses Caring for Undocumented Immigrants: A Concept Analysis.

Research and theory for nursing practice·2026
Same journal

Predicting Preschool Children's Screen Time: The Role of Parental Digital Habits and Bandura's Social Learning Theory.

Research and theory for nursing practice·2026
Same journal

Stress and Resilience in Parents of Children With Chronic Health Conditions: Adapting an Existing Model to Guide Future Research.

Research and theory for nursing practice·2026
Same journal

Giving Trauma Survivors a Voice: Initial Steps of Validating a Trauma-Informed Care Patient-Perception Instrument.

Research and theory for nursing practice·2026
Same journal

Unpredictability in Inpatient Nursing Work: An Evolutionary Concept Analysis.

Research and theory for nursing practice·2026
Same journal

Social Determinants of Health: A Concept Analysis.

Research and theory for nursing practice·2026
See all related articles

Related Experiment Videos

Translation science and context.

Marita G Titler1

  • 1University of Michigan, School of Nursing, Ann Arbor, MI 48109-5482, USA. mtitler@umich.edu

Research and Theory for Nursing Practice
|March 26, 2010
PubMed
Summary
This summary is machine-generated.

Implementing evidence-based practices (EBPs) in healthcare faces challenges due to contextual factors. Strategies addressing system complexity, practitioners, leadership, and culture are crucial for successful adoption and sustained use of EBPs.

Related Experiment Videos

Area of Science:

  • Health Services Research
  • Translational Science
  • Healthcare Management

Background:

  • Evidence-based practices (EBPs) exist for many conditions but are not consistently implemented.
  • Variations in healthcare practices are common, hindering routine adoption of evidence.
  • Contextual factors significantly influence the implementation challenges of EBPs.

Purpose of the Study:

  • To explore the importance of context in the implementation of evidence-based practices.
  • To identify necessary strategies for promoting and sustaining the adoption of EBPs in healthcare settings.
  • To guide future research in translation science for effective implementation interventions.

Main Methods:

  • Discussion of contextual factors influencing EBP implementation.
  • Application of the Translation Research Model to understand innovation adoption.
  • Review of factors affecting the dissemination and communication of EBPs.

Main Results:

  • Implementation difficulties are often explained by contextual factors within healthcare systems.
  • Successful EBP adoption requires addressing system complexity, individual practitioners, leadership, and organizational culture.
  • The nature of the innovation and its communication are key determinants of adoption.

Conclusions:

  • Context is a critical element in the successful translation and implementation of evidence-based practices.
  • Further research is needed to test translating research into practice (TRIP) interventions and understand their mechanisms.
  • Developing strategies that consider the multifaceted context is essential for creating an evidence-based practice environment.