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Related Concept Videos

Tuberculosis01:23

Tuberculosis

Tuberculosis (TB) remains a significant global health concern, primarily targeting the lungs and spreading through airborne transmission. Infection begins when aerosolized droplet nuclei, expelled by an individual with active TB, are inhaled by another person. These microscopic particles carry Mycobacterium tuberculosis, the causative agent of TB. Upon reaching the alveoli, the bacilli are engulfed by alveolar macrophages. However, due to their specialized lipid-rich cell wall, these pathogens...
Pulmonary Tuberculosis IV01:26

Pulmonary Tuberculosis IV

Tuberculosis, more commonly referred to as TB, is an infectious disease stemming from Mycobacterium tuberculosis. While it primarily impacts the lungs, TB can also affect other body areas. Given its severity and global impact, timely and accurate diagnosis is crucial for controlling its spread and improving patient outcomes.
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
Pulmonary Tuberculosis V01:28

Pulmonary Tuberculosis V

Medical management of tuberculosis (TB) patients involves a comprehensive approach that includes diagnosis, treatment, and monitoring. The specific strategies can vary depending on the type of tuberculosis (latent or active), the patient's overall health status, and other considerations.
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the progression...
Pulmonary Tuberculosis II01:28

Pulmonary Tuberculosis II

Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
Pulmonary Tuberculosis I01:29

Pulmonary Tuberculosis I

Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Pulmonary Tuberculosis III01:31

Pulmonary Tuberculosis III

Tuberculosis (TB) is a contagious infection primarily affecting the lung parenchyma but which can also affect other body parts. TB can be classified based on disease development, presentation, and the affected anatomical site.
The first classification is based on the development of the disease, and it includes the following categories:

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System for Efficacy and Cytotoxicity Screening of Inhibitors Targeting Intracellular Mycobacterium tuberculosis
09:57

System for Efficacy and Cytotoxicity Screening of Inhibitors Targeting Intracellular Mycobacterium tuberculosis

Published on: April 5, 2017

Anti-tuberculosis compounds from Mallotus philippinensis.

Qi Hong1, David E Minter, Scott G Franzblau

  • 1Department of Chemistry, Texas Christian University, Fort Worth, TX 76129, USA.

Natural Product Communications
|March 26, 2010
PubMed
Summary

A new compound, mallotophilippen F, from Mallotus philippinensis shows potent activity against Mycobacterium tuberculosis. This study also identified other known and new compounds, aiding in tuberculosis research.

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Area of Science:

  • Natural Product Chemistry
  • Medicinal Chemistry
  • Microbiology

Background:

  • Mallotus philippinensis is a plant source of bioactive compounds.
  • Natural products are explored for antimicrobial properties.

Purpose of the Study:

  • To isolate and characterize compounds from Mallotus philippinensis with activity against Mycobacterium tuberculosis.
  • To identify novel compounds and re-evaluate known ones.

Main Methods:

  • Bioassay-directed fractionation of plant extracts.
  • Spectroscopic analysis, including 2D-NMR and C-13 NMR.
  • Chemical structure elucidation and identification.

Main Results:

  • A new compound, mallotophilippen F (1), exhibited significant antimycobacterial activity.
  • Compound 2 was isolated from a natural source for the first time.
  • NMR spectral assignments for compounds 2-4 were corrected.
  • The C-13 NMR spectrum of compound 5 was reported for the first time.

Conclusions:

  • Mallotus philippinensis yields compounds with promising activity against Mycobacterium tuberculosis.
  • This research contributes to the discovery of new anti-tuberculosis agents.
  • Accurate structural characterization is crucial for natural product research.