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Updated: Jun 14, 2026

In Vitro Assay to Evaluate the Impact of Immunoregulatory Pathways on HIV-specific CD4 T Cell Effector Function
Published on: October 15, 2013
Enhanced anti-HIV functional activity associated with Gag-specific CD8 T-cell responses
B Julg1, K L Williams, S Reddy
1HIV Pathogenesis Program, Doris Duke Medical Research Institute and KwaZulu Natal Research Institute for TB and HIV, University of KwaZulu Natal, Durban, South Africa.
Abstract:
Effective HIV-specific T-cell immunity requires the ability to inhibit virus replication in the infected host, but the functional characteristics of cells able to mediate this effect are not well defined. Since Gag-specific CD8 T cells have repeatedly been associated with lower viremia, we examined the influence of Gag specificity on the ability of unstimulated CD8 T cells from chronically infected persons to inhibit virus replication in autologous CD4 T cells. Persons with broad (>or=6; n = 13) or narrow (
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