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Updated: Jun 14, 2026

Skeletal Muscle Gender Dimorphism from Proteomics
Published on: December 14, 2011
Mechanisms behind estrogen's beneficial effect on muscle strength in females
Dawn A Lowe1, Kristen A Baltgalvis, Sarah M Greising
1Program in Physical Therapy and Rehabilitation Sciences, University of Minnesota, Minneapolis, MN 55455, USA. lowex017@umn.edu
Abstract:
Muscle weakness ensues when serum testosterone declines with age in men. Testosterone's female counterpart, estrogen, also has been implicated in age-related strength loss, but these results are less conclusive. Our working hypothesis is that estrogens do benefit muscle strength, and that the underlying mechanism involves estrogen receptors to improve muscle quality more so than quantity.
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