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Updated: Jun 14, 2026

Screening and Isolation of C-Glycoside-Cleaving Intestinal Bacteria
Published on: February 28, 2025
A new flavone C-glycoside from Clematis rehderiana
Zhi-Zhi Du1, Xian-Wen Yang, Hao Han
1State Key Laboratory of Phytochemistry and Plant Resources of West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, China. duzhizhi@mail.kib.ac.cn
Abstract:
A new flavone C-glycoside, isovitexin 6''-O-E-p-coumarate (1) and two known flavonoid glycosides--quercetin 3-O-beta-D-glucuronopyranoside (2) and isoorientin (3)--were isolated from an ethanol extract of aerial parts of Clematis rehderiana. Their structures were determined by spectroscopic methods. The antioxidant effects of the two flavone C-glycosides were evaluated by both the MTT and DPPH assays. Compound 1 showed potent activities against H2O2-induced impairment in PC12 cells within the concentration range tested, whereas compound 3 scavenged DPPH radical strongly, with an IC50 value of 13.5 microM.

