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Updated: Jun 14, 2026

Nucleoside Triphosphates - From Synthesis to Biochemical Characterization
Published on: April 3, 2014
C-Nucleosides Derived from Simple Aromatic Hydrocarbons
Narayan C Chaudhuri1, Rex X-F Ren, Eric T Kool
1Department of Chemistry, University of Rochester, Rochester, NY 14627, USA, Fax (716)473-6889.
Abstract:
We describe the synthesis, structure and DNA incorporation of a class of novel aromatic C-deoxynucleosides in which benzenes and larger polycyclic aromatics serve as DNA base analogs. Novel approaches have been developed for glycosidic bond formation and for epimenzation of the anomeric substitutents to β-configuration, and we describe some of the properties of such compounds in DNA.
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