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Related Concept Videos

Parkinson Disease ll: Pathophysiology01:24

Parkinson Disease ll: Pathophysiology

Parkinson disease (PD) is a progressive neurodegenerative disorder primarily affecting movement, with additional non-motor features. Its pathophysiology involves complex interactions among genetic susceptibility, environmental exposures, and cellular dysfunction, including dopaminergic neuron loss, protein aggregation, and mitochondrial impairment.Selective NeurodegenerationA key feature is the degeneration of dopaminergic neurons in the substantia nigra pars compacta, leading to reduced...
Parkinson's Disease: Overview01:15

Parkinson's Disease: Overview

Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is to...
Parkinson Disease l: Introduction01:24

Parkinson Disease l: Introduction

Parkinson’s disease is a chronic, progressive neurodegenerative disorder that primarily affects movement. It is characterized by motor symptoms such as resting tremors, muscle rigidity, bradykinesia (slowness of movement), and postural instability. Patients may notice hand tremors at rest, stiffness during movement, or a shuffling gait. In addition to motor features, non-motor symptoms include sleep disturbances, mood and behavioral changes, constipation, and cognitive impairment, all of which...
Neural Regulation01:37

Neural Regulation

Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.
Parkinson's Disease: Treatment01:24

Parkinson's Disease: Treatment

Neurodegenerative disorders, such as Parkinson's Disease (PD), involve the gradual and irreversible destruction of neurons in particular brain areas. These disorders exhibit standard features like proteinopathies, selective vulnerability of some neurons, and an interaction of intrinsic properties, genetics, and environmental influences in neural injury.
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of its...
Time-Domain Interpretation of PD Control01:07

Time-Domain Interpretation of PD Control

Proportional-Derivative (PD) control is a widely used control method in various engineering systems to enhance stability and performance. In a system with only proportional control, common issues include high maximum overshoot and oscillation, observed in both the error signal and its rate of change. This behavior can be divided into three distinct phases: initial overshoot, subsequent undershoot, and gradual stabilization.
Consider the example of control of motor torque. Initially, a positive...

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Related Experiment Video

Updated: Jun 14, 2026

Dynamic Digital Biomarkers of Motor and Cognitive Function in Parkinson's Disease
10:28

Dynamic Digital Biomarkers of Motor and Cognitive Function in Parkinson's Disease

Published on: July 24, 2019

Dynamic emotion processing in Parkinson's disease as a function of channel availability.

Silke Paulmann1, Marc D Pell

  • 1School of Communication Sciences and Disorders, McGill University, Montréal, Canada. paulmann@essex.ac.uk

Journal of Clinical and Experimental Neuropsychology
|March 26, 2010
PubMed
Summary

Adults with Parkinson's disease (PD) show significant impairments in recognizing dynamic emotional expressions across all sensory channels. These deficits may stem from striatal dysfunction affecting sequential information processing in PD patients.

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Controlling Parkinson's Disease With Adaptive Deep Brain Stimulation
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Last Updated: Jun 14, 2026

Dynamic Digital Biomarkers of Motor and Cognitive Function in Parkinson's Disease
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Dynamic Digital Biomarkers of Motor and Cognitive Function in Parkinson's Disease

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Controlling Parkinson's Disease With Adaptive Deep Brain Stimulation
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Published on: July 16, 2014

Area of Science:

  • Neuroscience
  • Psychology
  • Clinical Neurology

Background:

  • Parkinson's disease (PD) is associated with deficits in emotional expression recognition.
  • The precise nature and extent of these communication impairments in PD remain unclear.

Purpose of the Study:

  • To compare the ability of adults with and without PD to recognize dynamic emotional expressions.
  • To investigate recognition across lexical-semantic, prosody, and facial cue channels, individually and combined.

Main Methods:

  • Utilized dynamic emotional stimuli presented through distinct sensory channels (lexical-semantic, prosody, facial cues).
  • Assessed emotion recognition performance in individuals with PD and healthy controls under various channel conditions.

Main Results:

  • Individuals with PD demonstrated significantly poorer emotion recognition compared to healthy controls across all tested conditions.
  • Emotion recognition performance in the PD group improved with the availability of multiple sensory channels.

Conclusions:

  • Dynamic emotional stimulus processing is impaired in Parkinson's disease.
  • Deficits may be linked to striatal dysfunction impacting the binding of sequential information in PD.