Related Experiment Video
Updated: Jun 14, 2026
08:30
Glaucoma-inducing Procedure in an In Vivo Rat Model and Whole-mount Retina Preparation
Published on: March 12, 2016
Idiopathic Hypertrophic Pachymeningitis Presenting with Uveitic Glaucoma
Summary
A 73-year-old man experienced vision loss and headache, initially treated for uveitic glaucoma. Further investigation revealed idiopathic hypertrophic pachymeningitis and optic neuritis, not active inflammation.
Area of Science:
- Ophthalmology
- Neurology
- Radiology
Background:
- A 73-year-old male presented with uveitic glaucoma and persistent headaches.
- Initial treatment focused on ocular inflammation and intraocular pressure management without neuroimaging.
Purpose of the Study:
- To investigate the cause of persistent headaches and subsequent acute bilateral visual loss.
- To diagnose the underlying condition leading to optic neuritis in a patient with a history of uveitic glaucoma.
Main Methods:
- Ophthalmologic examination, including assessment of intraocular pressure.
- Gd-DPTA-enhanced cranial magnetic resonance imaging (MRI) to evaluate brain and optic nerve structures.
Main Results:
- Despite treatment for uveitic glaucoma, the patient developed acute bilateral visual loss.
- MRI revealed thickened, enhancing dura and optic nerve sheath, indicative of pachymeningitis.
- Ophthalmologic findings included bilateral optic neuritis.
Conclusions:
- The patient was diagnosed with idiopathic hypertrophic pachymeningitis associated with optic neuritis.
- This case highlights the importance of considering neuroimaging in persistent headaches and visual disturbances, even after initial ocular treatment.
Related Concept Videos
01:25Glaucoma: Overview
Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
01:28Angle Closure Glaucoma: Treatment
Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
01:27Open Angle Glaucoma: Treatment
In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
Drugs such as carbonic anhydrase inhibitors, α2- and...
01:26Brain Abscess l: Introduction
A brain abscess is a focal, intracerebral infection characterized by a localized collection of pus within the brain parenchyma, resulting from microbial invasion and the body’s inflammatory response. It progresses through stages: early and late cerebritis, followed by early and late capsule formation, reflecting tissue destruction, immune response, and eventual encapsulation.Etiology and PathogenesisCausative organisms vary with source and host factors, often involving polymicrobial infections,...
01:22Bacterial Meningitis I: Introduction
Bacterial meningitis is a severe, life-threatening inflammation of the meninges, particularly the pia mater and arachnoid mater, affecting the subarachnoid space, ventricles, and cerebrospinal fluid (CSF). If untreated, it can lead to significant neurological complications or death.Causative AgentsCommon pathogens vary with age and immune status. In adults, major organisms include Streptococcus pneumoniae, Neisseria meningitidis, and Haemophilus influenzae. Streptococcus agalactiae (group B...
01:22Cerebral Edema ll: Pathophysiology
Vasogenic edema is a major form of cerebral edema characterized by abnormal accumulation of fluid in the brain’s extracellular space due to disruption of the blood–brain barrier (BBB). The BBB is a specialized structure composed of endothelial cells connected by tight junctions, supported by astrocytic endfeet and a basement membrane. Under normal conditions, it tightly regulates the movement of ions, proteins, and solutes between the bloodstream and brain parenchyma. When this barrier loses...