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Related Experiment Video

Updated: Jun 14, 2026

Correction of Presbyopia by Monocular Bi-Aspheric Ablation Profile
05:46

Correction of Presbyopia by Monocular Bi-Aspheric Ablation Profile

Published on: September 20, 2024

Corneal Melt While Using Topical Bevacizumab Eye Drops.

Anat Galor, Sonia H Yoo

    Ophthalmic Surgery, Lasers & Imaging : the Official Journal of the International Society for Imaging in the Eye
    |March 27, 2010
    PubMed
    Summary
    This summary is machine-generated.

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    Drugs·2026

    Topical bevacizumab effectively reduced corneal neovascularization in a patient with a corneal perforation. However, caution is advised due to a subsequent corneal melt in the donor graft.

    Area of Science:

    • Ophthalmology
    • Regenerative Medicine

    Background:

    • Idiopathic central corneal perforation presents a significant clinical challenge.
    • Corneal neovascularization can complicate healing and impact visual outcomes.
    • Bevacizumab is an anti-vascular endothelial growth factor (VEGF) agent with potential applications in ophthalmology.

    Purpose of the Study:

    • To evaluate the efficacy of topical bevacizumab in resolving corneal neovascularization post-perforation repair.
    • To assess the safety and potential complications of using bevacizumab in patients with a history of corneal melt.

    Main Methods:

    • A case report of a 75-year-old male with idiopathic central corneal perforation.
    • Treatment involved cyanoacrylate glue, bandage contact lens, and topical bevacizumab (25 mg/mL).

    Related Experiment Videos

    Last Updated: Jun 14, 2026

    Correction of Presbyopia by Monocular Bi-Aspheric Ablation Profile
    05:46

    Correction of Presbyopia by Monocular Bi-Aspheric Ablation Profile

    Published on: September 20, 2024

  • Surgical intervention included penetrating keratoplasty, with continued bevacizumab use post-operatively.

    • Main Results:

    • Topical bevacizumab led to marked regression of 360-degree corneal neovascularization.
    • Despite initial healing, the patient developed graft stromal melt 5 weeks post-keratoplasty.
    • Repeat penetrating keratoplasty and Gunderson flap were necessitated by graft melt.

    Conclusions:

    • Topical bevacizumab can be effective in regressing acute corneal neovascularization.
    • Caution is warranted when using bevacizumab in patients with a history of corneal melt due to potential risks.
    • This case underscores the complex interplay between anti-VEGF therapy and corneal wound healing.