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Updated: Jun 14, 2026
08:40
Establishment and Characterization of UTI and CAUTI in a Mouse Model
Published on: June 23, 2015
Current therapy of acute uncomplicated cystitis
Shingo Yamamoto1, Yoshihide Higuchi, Michio Nojima
1Department of Urology, Hyogo College of Medicine, Nishinomiya, Hyogo, Japan. shingoy@hyo-med.ac.jp
Summary
Acute uncomplicated cystitis (AUC) treatment is shifting due to rising antibiotic resistance. Fluoroquinolones are now preferred over trimethoprim-sulfamethoxazole, but resistance is a growing concern for all antibiotics.
Area of Science:
- Urology
- Infectious Diseases
- Pharmacology
Background:
- Acute uncomplicated cystitis (AUC) is a common bacterial urinary tract infection, particularly in women.
- Historically, trimethoprim-sulfamethoxazole (TMP/SMX) was the standard treatment.
- Increasing resistance to TMP/SMX has led to the increased use of fluoroquinolones.
Purpose of the Study:
- To review current treatment guidelines for AUC.
- To address the challenges posed by antimicrobial resistance.
- To provide recommendations for empirical therapy.
Main Methods:
- Literature review of treatment guidelines and resistance patterns.
- Analysis of antimicrobial susceptibility data.
- Evaluation of current therapeutic recommendations.
Main Results:
- Fluoroquinolones are now frequently used for AUC due to TMP/SMX resistance.
- Worldwide fluoroquinolone resistance is increasing.
- Extended-spectrum beta-lactamase (ESBL)-producing strains present additional challenges due to resistance to multiple antibiotic classes.
Conclusions:
- Current empirical therapy recommendations include 3-day fluoroquinolone or 7-day beta-lactam regimens.
- These regimens require re-evaluation due to evolving resistance patterns.
- Low-dose fluoroquinolone use should be discontinued to prevent further resistance emergence.
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