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Cutaneous intravascular anaplastic large cell lymphoma
Lei Wang1, Chengxin Li, Tianwen Gao
1Department of Dermatology, Xijing Hospital, Fourth Military Medical University, Xian, China.
Journal of Cutaneous Pathology
|March 27, 2010
Summary
Intravascular anaplastic large cell lymphoma (IALCL) is a rare skin lymphoma. This case study suggests IALCL is a distinct subtype of intravascular lymphoma (IL), differing in histopathology and biology.
Area of Science:
- Oncology
- Dermatology
- Hematopathology
Background:
- Intravascular lymphoma (IL) is a rare non-Hodgkin lymphoma, predominantly affecting the skin.
- Most IL cases involve large B-cell lymphomas.
- Intravascular anaplastic large cell lymphoma (IALCL) is exceptionally rare.
Observation:
- A 47-year-old woman presented with multiple erythematous skin lesions.
- Lesions initially responded to CHOP chemotherapy but relapsed.
- Histopathology revealed evolution from IL to extravascular lymphoma over time.
Findings:
- IALCL cells were positive for CD30, CD45, CD3, CD4, CD5, and Ki67.
- Cells lacked ALK expression and markers for B-cell, NK-cell, and cytotoxic T-cell phenotypes.
- The neoplasm showed a distinct T-cell profile.
Implications:
- IALCL may represent a unique subtype of IL.
- IALCL appears histopathologically and biologically distinct from other IL subtypes.
- This case highlights the importance of detailed immunophenotyping in rare lymphomas.
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