DNA nanomedicine: Engineering DNA as a polymer for therapeutic and diagnostic applications

Michael J Campolongo1, Shawn J Tan, Jianfeng Xu

  • 1Department of Biomedical Engineering, Cornell University, Ithaca, NY 14853, USA.

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Site-Targeted Drug Delivery Systems: Polymeric Carriers

Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...