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Minocycline-associated pseudotumor cerebri with severe papilledema

Simon R Bababeygy1, Michael X Repka, Prem S Subramanian

  • 1Department of Ophthalmology, The Johns Hopkins Hospitals, 600 N. Wolfe St, Baltimore, MD 21287, USA.

Journal of Ophthalmology
|March 27, 2010
PubMed

Insights

Pseudotumor cerebri from oral minocycline can be severe and persistent. This condition may require aggressive treatment beyond simply stopping the drug.

Area of Science:

  • Neurology
  • Ophthalmology

Background:

  • Pseudotumor cerebri is a known complication of oral minocycline.
  • Previous reports suggest mild and transient symptoms, potentially not requiring treatment.

Observation:

  • This case series examined two nonobese patients with severe papilledema and visual field loss.
  • Both patients were taking oral minocycline.

Findings:

  • Severe pseudotumor cerebri developed in both patients.
  • Symptoms persisted despite minocycline discontinuation, necessitating further medical or surgical intervention.

Implications:

  • Minocycline-associated pseudotumor cerebri is not always self-limiting.
  • Aggressive management may be required for vision preservation.

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