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Updated: Jun 14, 2026

Use of Ultra-high Field MRI in Small Rodent Models of Polycystic Kidney Disease for In Vivo Phenotyping and Drug Monitoring
Published on: June 23, 2015
[Recent insights into polycystic kidney disease]
Olivier Bonny1, Hassib Chehade, Florence Fellmann
1Service de néphrologie, Département de médecine, CHUV, Lausanne. olivier.bonny@chuv.ch
Autosomal dominant polycystic kidney disease (ADPKD) management is evolving with new diagnostic criteria and treatments. This review covers updated ultrasound, MRI volumetry, genetic testing, and emerging therapies for ADPKD.
Area of Science:
- Nephrology
- Genetics
- Medical Imaging
Context:
- Autosomal dominant polycystic kidney disease (ADPKD) is a common genetic disorder.
- General practitioners frequently encounter patients with ADPKD.
- Patient follow-up and treatment paradigms for ADPKD are undergoing significant changes.
Purpose:
- To review updated diagnostic criteria for ADPKD using ultrasound.
- To discuss the role of renal volumetry by MRI in ADPKD patient monitoring.
- To explore the current status of genetic molecular diagnosis and emerging therapeutic strategies for ADPKD.
Summary:
- New ultrasound criteria enhance ADPKD diagnosis.
- Renal volumetry via MRI is a key tool for monitoring disease progression.
- Genetic testing and novel treatments in Phase III trials promise to transform ADPKD outcomes.
Impact:
- Provides a comprehensive overview of recent advancements in ADPKD diagnosis and management.
- Highlights the potential of new treatments to significantly alter the disease's prognosis.
- Equips healthcare providers with current information for improved patient counseling and care.
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