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Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty
Published on: January 28, 2020
Inflammatory biomarkers predicting events in atherosclerosis
E Stefanadi1, D Tousoulis, N Papageorgiou
1Athens University Medical School, Hippokration Hospital, Vasilissis Sofias 114, 115 28, Athens, Greece.
Current Medicinal Chemistry
|March 30, 2010
Summary
Vascular inflammation is key in atherosclerosis development. While C-reactive protein and fibrinogen predict cardiovascular events, the roles of adhesion molecules and cytokines require further investigation.
Area of Science:
- Cardiovascular Medicine
- Immunology
- Biochemistry
Background:
- Vascular inflammation is increasingly recognized as a critical factor in atherosclerosis pathogenesis and progression.
- Several circulating inflammatory biomarkers, including acute phase proteins, adhesion molecules, and cytokines, have elucidated inflammation's role in this disease.
Purpose of the Study:
- To review the current understanding of inflammatory biomarkers in atherosclerosis.
- To highlight the established predictive roles of C-reactive protein and fibrinogen.
- To identify the need for further research into the prognostic value of adhesion molecules and cytokines.
Main Methods:
- Literature review of studies on inflammatory biomarkers and atherosclerosis.
- Analysis of evidence supporting the predictive role of C-reactive protein and fibrinogen.
- Identification of knowledge gaps regarding adhesion molecules and cytokines.
Main Results:
- C-reactive protein (CRP) has a positive predictive role in individuals without prior cardiovascular disease.
- Fibrinogen has demonstrated a positive role in predicting cardiovascular events.
- The prognostic significance of adhesion molecules and cytokines in cardiovascular events remains uncertain.
Conclusions:
- Established biomarkers like CRP and fibrinogen are valuable in predicting cardiovascular risk in atherosclerosis.
- Further research is essential to clarify the prognostic role of adhesion molecules and cytokines.
- Investigating novel biomarkers is crucial for a comprehensive understanding of atherosclerosis states.
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