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Published on: January 28, 2020

Inflammatory biomarkers predicting events in atherosclerosis

E Stefanadi1, D Tousoulis, N Papageorgiou

  • 1Athens University Medical School, Hippokration Hospital, Vasilissis Sofias 114, 115 28, Athens, Greece.

Current Medicinal Chemistry
|March 30, 2010
PubMed

Insights

Vascular inflammation is key in atherosclerosis development. While C-reactive protein and fibrinogen predict cardiovascular events, the roles of adhesion molecules and cytokines require further investigation.

Area of Science:

  • Cardiovascular Medicine
  • Immunology
  • Biochemistry

Background:

  • Vascular inflammation is increasingly recognized as a critical factor in atherosclerosis pathogenesis and progression.
  • Several circulating inflammatory biomarkers, including acute phase proteins, adhesion molecules, and cytokines, have elucidated inflammation's role in this disease.

Purpose of the Study:

  • To review the current understanding of inflammatory biomarkers in atherosclerosis.
  • To highlight the established predictive roles of C-reactive protein and fibrinogen.
  • To identify the need for further research into the prognostic value of adhesion molecules and cytokines.

Main Methods:

  • Literature review of studies on inflammatory biomarkers and atherosclerosis.
  • Analysis of evidence supporting the predictive role of C-reactive protein and fibrinogen.
  • Identification of knowledge gaps regarding adhesion molecules and cytokines.

Main Results:

  • C-reactive protein (CRP) has a positive predictive role in individuals without prior cardiovascular disease.
  • Fibrinogen has demonstrated a positive role in predicting cardiovascular events.
  • The prognostic significance of adhesion molecules and cytokines in cardiovascular events remains uncertain.

Conclusions:

  • Established biomarkers like CRP and fibrinogen are valuable in predicting cardiovascular risk in atherosclerosis.
  • Further research is essential to clarify the prognostic role of adhesion molecules and cytokines.
  • Investigating novel biomarkers is crucial for a comprehensive understanding of atherosclerosis states.

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