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Updated: Jun 14, 2026
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Fabrication of a Biomimetic Nano-Matrix with Janus Base Nanotubes and Fibronectin for Stem Cell Adhesion
Published on: May 10, 2020
Nano-controlled molecular interaction at adhesive interfaces for hard tissue reconstruction
Kumiko Yoshihara1, Yasuhiro Yoshida, Noriyuki Nagaoka
1Department of Occlusal and Oral Functional Rehabilitation, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
Acta Biomaterialia
|March 30, 2010
Summary
Functional monomers enhance dental restoration durability by forming stable bonds with tooth hydroxyapatite, improving longevity and understanding interfacial degradation mechanisms.
Area of Science:
- Biomaterials Science
- Dental Materials
- Nanotechnology
Background:
- Dental composite restorations offer minimally invasive reconstruction but suffer from short clinical longevity.
- Water sorption is a primary factor destabilizing the bond between dental biomaterials and tooth structure.
- The precise mechanisms underlying interfacial degradation in dental restorations remain incompletely understood.
Purpose of the Study:
- To investigate nano-controlled molecular interactions at the biomaterial-hard tissue interface for improved bond durability.
- To identify functional monomers capable of forming stable bonds with hydroxyapatite for long-term dental restoration success.
Main Methods:
- Utilizing correlative X-ray diffraction and solid-state nuclear magnetic resonance.
- Analyzing time-dependent molecular interactions at the tooth-biomaterial interface.
- Investigating the formation of ionic bonds between functional monomers and hydroxyapatite.
Main Results:
- Demonstrated time-dependent molecular interactions at the interface, leading to stable ionic bond formation.
- Identified functional monomers with strong chemical affinity for calcium in hydroxyapatite.
- Observed competition between stable ionic bond formation and the deposition of less stable calcium phosphate salts.
Conclusions:
- Nano-controlled molecular interactions, particularly stable ionic bonding with hydroxyapatite, are crucial for enhancing dental restoration durability.
- The developed tooth-biomaterial interaction model provides insights into bond degradation mechanisms.
- This research lays the foundation for developing advanced functional monomers for more durable tooth reconstructions.
