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Updated: Jun 14, 2026
09:02
A Large Animal Model for Acute Kidney Injury by Temporary Bilateral Renal Artery Occlusion
Published on: February 2, 2021
Acute kidney injury in elderly persons.
1Section of Nephrology, Yale University School of Medicine, New Haven, CT, USA. steven.coca@yale.edu
Summary
Acute kidney injury (AKI) disproportionately affects the elderly, increasing mortality and chronic kidney disease risk. Future AKI research should focus on this demographic due to its high incidence and similar AKI presentation.
Area of Science:
- Nephrology
- Geriatrics
- Internal Medicine
Background:
- Acute kidney injury (AKI) incidence is highest among elderly patients.
- AKI in the elderly is linked to increased mortality and chronic kidney disease.
- The comparative risk of AKI outcomes in older versus younger individuals remains unclear.
Purpose of the Study:
- To highlight the significance of AKI in the elderly population.
- To discuss the outcomes associated with AKI in older adults.
- To advocate for future clinical trials to be conducted in the elderly.
Main Methods:
- Review of existing literature on AKI in the elderly.
- Analysis of AKI incidence and outcomes in different age groups.
- Discussion of the current therapeutic landscape for AKI.
Main Results:
- Elderly patients represent the largest segment of AKI cases.
- AKI is associated with elevated short- and long-term mortality and progression to end-stage renal disease in the elderly.
- Health-related quality of life may be impacted post-AKI.
Conclusions:
- Given the high incidence and similar presentation, the elderly are a suitable population for future AKI intervention trials.
- Effective AKI therapies are currently lacking for widespread use.
- Further research focusing on elderly AKI patients is warranted.
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