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Ex Vivo Release of Calcitonin Gene-Related Peptide from the Trigeminovascular System in Rodents
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Published on: May 16, 2022

TRPV1 in migraine pathophysiology.

Jannis E Meents1, Lars Neeb, Uwe Reuter

  • 1Department of Neurology, Charité Universitätsmedizin Berlin, Charitéplatz 1, 10117 Berlin, Germany.

Trends in Molecular Medicine
|March 30, 2010
PubMed
Summary
This summary is machine-generated.

Migraine involves the trigeminovascular system (TVS) and TRPV1 channel sensitization. Targeting TRPV1 sensitization offers a promising therapeutic strategy for migraine treatment and drug development.

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Last Updated: Jun 14, 2026

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Investigating Migraine-Like Behavior Using Light Aversion in Mice
05:23

Investigating Migraine-Like Behavior Using Light Aversion in Mice

Published on: August 11, 2021

Area of Science:

  • Neuroscience
  • Pharmacology

Background:

  • Migraine is a common neurological disorder linked to trigeminovascular system (TVS) dysfunction.
  • Inflammatory processes in migraine may sensitize trigeminal nociceptors, leading to hyperalgesia and allodynia.
  • The TRPV1 channel on trigeminal nociceptors is implicated in sensitization and pain development.

Purpose of the Study:

  • To review molecular mechanisms of TRPV1 sensitization.
  • To connect TRPV1 sensitization to migraine pathophysiology.
  • To evaluate TRPV1 antagonism as a migraine treatment strategy.

Main Methods:

  • Literature review of molecular mechanisms.
  • Analysis of TRPV1 channel function in pain pathways.
  • Linking TRPV1 sensitization to migraine pathogenesis.

Main Results:

  • TRPV1 channels play a key role in peripheral and central sensitization.
  • Molecular mechanisms driving TRPV1 sensitization are relevant to migraine.
  • TRPV1 sensitization contributes to migraine-associated pain.

Conclusions:

  • Antagonizing TRPV1 sensitization is a promising therapeutic avenue for migraine.
  • Further research into TRPV1 modulation is warranted for anti-migraine drug development.