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Monitoring Stub1-Mediated Pexophagy
Published on: May 12, 2023
Truxillic acid derivatives act as peroxisome proliferator-activated receptor gamma activators
Ramona Steri1, Matthias Rupp, Ewgenij Proschak
1Goethe-University Frankfurt, Institute of Pharmaceutical Chemistry/ZAFES/LiFF/FIRST, Max-von-Laue-Str. 9, 60438 Frankfurt, Germany. steri@pharmchem.uni-frankfurt.de
Abstract:
In previous studies, we identified a truxillic acid derivative as selective activator of the peroxisome proliferator-activated receptor gamma, which is a member of the nuclear receptor family and acts as ligand-activated transcription factor of genes involved in glucose metabolism. Herein we present the structure-activity relationships of 16 truxillic acid derivatives, investigated by a cell-based reporter gene assay guided by molecular docking analysis.
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