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Current concepts in systemic and topical therapy for superficial mycoses
1Department of Dermatology, Tulane University School of Medicine, New Orleans, LA 70112, USA. millikanmd@gmail.com
Clinics in Dermatology
|March 30, 2010
Summary
Topical antifungal treatments like allylamines and imidazoles are effective for superficial mycoses. While established antifungals like nystatin and griseofulvin have specific uses, advancements in drug delivery systems improve treatment outcomes.
Area of Science:
- Dermatology
- Pharmacology
- Mycology
Background:
- Superficial mycoses present diverse treatment options.
- Allylamines and imidazoles are established broad-spectrum antifungal agents with a proven safety profile over two decades.
- Nystatin and griseofulvin are older antifungals with specific applications for yeasts and dermatophytes, respectively.
Purpose of the Study:
- To review current treatment choices for superficial fungal infections.
- To highlight the efficacy and safety of established antifungal drug classes.
- To discuss advancements in drug delivery systems for topical antifungals.
Main Methods:
- Literature review of existing antifungal therapies.
- Analysis of clinical data on allylamines, imidazoles, nystatin, and griseofulvin.
- Evaluation of novel vehicle and delivery system developments.
Main Results:
- Allylamines and imidazoles demonstrate broad-spectrum efficacy and good safety in superficial mycoses treatment.
- Nystatin and griseofulvin remain relevant for specific fungal infections (yeasts and dermatophytes).
- Innovations in drug delivery systems have significantly improved therapeutic effectiveness and patient adherence.
Conclusions:
- Established antifungal agents like allylamines and imidazoles remain first-line treatments for many superficial mycoses.
- Advancements in formulation technology enhance the clinical utility of existing antifungal medications.
- Continued development in drug delivery systems offers promising avenues for improved management of superficial fungal infections.
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