Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Video

Updated: Jun 14, 2026

Temporal Ordering of Dynamic Expression Data from Detailed Spatial Expression Maps

Temporal Ordering of Dynamic Expression Data from Detailed Spatial Expression Maps

Published on: February 9, 2017

Spatial p21 expression profile in the mid-term mouse embryo.

Douglas B Vasey¹, C Roland Wolf, Ken Brown

¹Division of Developmental Biology, The Roslin Institute and Royal (Dick), School of Veterinary Studies, University of Edinburgh, Roslin, EH25 9PS, UK. d.vasey@dundee.ac.uk

Transgenic Research

|March 30, 2010

Summary

This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Correction: The potent human CAR activator CITCO is a non-genotoxic hepatic tumour-promoting agent in humanised constitutive androstane receptor mice but not in wild-type animals.

Archives of toxicology·2026

Same author

Letter to the editor regarding the review article: Yamada T, Cohen SM, Lake BG. The modes of action for rodent liver tumor formation by activators of the constitutive androstane receptor (CAR) and the peroxisome proliferator-activated receptor alpha (PPARα) are not relevant to human cancer risk: an updated critical evaluation. Crit Rev Toxicol. 2025;55(5):549-586. doi: 10.1080/10408444.2025.2513332.

Critical reviews in toxicology·2026

Same author

Humanization of Drug Metabolism in the <i>Plasmodium berghei</i> Mouse Model for Antimalarial Drug Discovery.

ACS infectious diseases·2025

Same author

DNAJC14 gene-edited pigs are resistant to classical pestiviruses.

Trends in biotechnology·2025

Same author

Integration of in vivo stress reporters with transcription profiling to define chemical mixtures mechanisms of toxicity, including trans-generational effects.

Chemico-biological interactions·2025

Same author

AKT/mTOR as a targetable hub to overcome multimodal resistance to EGFR inhibitors in oesophageal squamous cell carcinoma.

British journal of cancer·2025

Cyclin-dependent kinase inhibitor 1A (p21) regulates cell cycle progression. This study maps p21 expression in mouse embryos, revealing its role in cell differentiation, remodeling, and a potential protective function against apoptosis.

Area of Science:

Developmental biology
Cell cycle regulation
Molecular biology

Background:

Cell proliferation, arrest, and death are critical for development.
Dysregulation of these processes contributes to disease.
The cell cycle is regulated by factors like cyclin-dependent kinase inhibitor 1A (p21).

Purpose of the Study:

To determine the temporal and spatial expression pattern of p21 in the developing mid-term mouse embryo.
To investigate the relationship between p21 expression and developmental processes like differentiation, remodeling, and apoptosis.

Main Methods:

Utilized a p21-LacZ reporter mouse line.
Analyzed the expression profile of p21 during embryonic development.

Main Results:

More Related Videos

Stem cell-like Xenopus Embryonic Explants to Study Early Neural Developmental Features In Vitro and In Vivo

Stem cell-like Xenopus Embryonic Explants to Study Early Neural Developmental Features In Vitro and In Vivo

Published on: February 2, 2016

Related Experiment Videos

Last Updated: Jun 14, 2026

Temporal Ordering of Dynamic Expression Data from Detailed Spatial Expression Maps

Temporal Ordering of Dynamic Expression Data from Detailed Spatial Expression Maps

Published on: February 9, 2017

Stem cell-like Xenopus Embryonic Explants to Study Early Neural Developmental Features In Vitro and In Vivo

Stem cell-like Xenopus Embryonic Explants to Study Early Neural Developmental Features In Vitro and In Vivo

Published on: February 2, 2016

p21 expression was localized to specific regions in the developing mouse embryo.
Expression correlated with areas of terminal differentiation and active tissue remodeling.
A complex relationship was observed between p21 expression and apoptotic regions.

Conclusions:

p21 plays a role in specific developmental processes.
The findings suggest a potential protective role for p21 in relation to apoptosis.